|
Hodgkin Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Little is known about the distribution in normal cells of CLIP-170, a linkage mediator between endocytic vesicles and microtubules, and restin, a splice variant encoded by the same gene and marker for Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin disease.
|
12433698 |
2002 |
|
Hodgkin Disease
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Study of the mechanisms leading to restin overexpression may provide important data on the etiology of Hodgkin's disease and its relation to anaplastic large cell lymphoma.
|
8161933 |
1993 |
|
Hodgkin Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
The presence of Restin in both Hodgkin's disease and anaplastic large-cell lymphoma is intriguing and might indicate a role of this structural protein in the pathogenesis of both conditions.
|
1450414 |
1992 |
|
Hodgkin Disease
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We suggest that restin overexpression may be a contributing factor in the progression of Hodgkin's disease.
|
1600942 |
1992 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Apoptosis-related protein-1 acts as a tumor suppressor in cholangiocarcinoma cells by inducing cell cycle arrest via downregulation of cyclin-dependent kinase subunits.
|
26572808 |
2016 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Tumor xenograft model was used to characterize the biological functions of Restin in vivo.
|
25972084 |
2015 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Systemic administration of restin suppressed the growth of tumors in a xenograft renal carcinoma model.
|
10049780 |
1999 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Study of the mechanisms leading to restin overexpression may provide important data on the etiology of Hodgkin's disease and its relation to anaplastic large cell lymphoma.
|
8161933 |
1993 |
|
Adult Anaplastic Large Cell Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Study of the mechanisms leading to restin overexpression may provide important data on the etiology of Hodgkin's disease and its relation to anaplastic large cell lymphoma.
|
8161933 |
1993 |
|
Childhood Anaplastic Large Cell Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Study of the mechanisms leading to restin overexpression may provide important data on the etiology of Hodgkin's disease and its relation to anaplastic large cell lymphoma.
|
8161933 |
1993 |
|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The presence of Restin in both Hodgkin's disease and anaplastic large-cell lymphoma is intriguing and might indicate a role of this structural protein in the pathogenesis of both conditions.
|
1450414 |
1992 |
|
Adult Anaplastic Large Cell Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The presence of Restin in both Hodgkin's disease and anaplastic large-cell lymphoma is intriguing and might indicate a role of this structural protein in the pathogenesis of both conditions.
|
1450414 |
1992 |
|
Childhood Anaplastic Large Cell Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The presence of Restin in both Hodgkin's disease and anaplastic large-cell lymphoma is intriguing and might indicate a role of this structural protein in the pathogenesis of both conditions.
|
1450414 |
1992 |
|
Central nervous system lesion
|
0.010 |
Biomarker
|
disease |
BEFREE |
Between Apr 1, 2017, and Dec 30, 2017, 22 patients met selection criteria, 15 with ≥ 1 measurable CNS lesion (RECIST 1.1) were included in CNS evaluable for response (cEFR) set.
|
30864019 |
2019 |
|
Adenomatous Polyposis Coli
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we show that <i>Caenorhabditis elegans</i> APR-1/APC is an attenuator of the pulling forces acting on the mitotic spindle.
|
29348204 |
2018 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Low MAGEH1 expression was significantly correlated with poor prognosis in HCC patients.
|
29316827 |
2018 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Previous study suggests that apoptosis-related protein-1 (Apr-1) is involved in cancer cell proliferation and survival.
|
26572808 |
2016 |
|
Cholangiocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Forced expression of Apr-1 inhibited cell proliferation of cholangiocarcinoma cell line QBC939 and induced G2/M phase arrest.
|
26572808 |
2016 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Taken together, our data showed that Apr-1 plays a crucial role in cell proliferation by controlling cell cycle progression, implying a tumor-suppressor function of Apr-1 in cholangiocarcinoma carcinogenesis.
|
26572808 |
2016 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Previous study suggests that apoptosis-related protein-1 (Apr-1) is involved in cancer cell proliferation and survival.
|
26572808 |
2016 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Real-time PCR and western blot were conducted to detect Restin expression in multiple breast cancer cell lines and Restin level was negatively related with cell motility.
|
25972084 |
2015 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Taken together, our results suggest that Restin inhibits EMT and tumor metastasis by controlling the expression of the tumor metastasis suppressor mir-200a/b via association with p73.
|
25972084 |
2015 |
|
Secondary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that Restin overexpression led to reduced lung metastasis.
|
25972084 |
2015 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Real-time PCR and western blot were conducted to detect Restin expression in multiple breast cancer cell lines and Restin level was negatively related with cell motility.
|
25972084 |
2015 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Our data showed that Restin overexpressed cells exhibited classical epithelial cell morphology, and Restin overexpression resulted in activation of epithelial markers and suppression of mesenchymal markers, and inhibition of cell migration and invasion.
|
25972084 |
2015 |