Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Genetic variation in the NR2B gene predicts reduced levels of the obligatory NR1 subunit, suggesting a novel mechanism by which the NR2B SNP may negatively influence other NMDAR subunit expression and reasoning ability in schizophrenia.
|
23070074 |
2013 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results suggest that SLC1A1, GRIN2B, and interactions between the two may potentially confer a susceptibility to OC symptoms in schizophrenia patients receiving clozapine.
|
23660601 |
2013 |
MENTAL RETARDATION, AUTOSOMAL DOMINANT 6
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
De novo mutations in epileptic encephalopathies.
|
23934111 |
2013 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
One possible source of compromised glutamatergic function in SZ is decreased surface expression of GluN2B-containing NMDARs.
|
22781170 |
2012 |
MENTAL RETARDATION, AUTOSOMAL DOMINANT 6
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
Diagnostic exome sequencing in persons with severe intellectual disability.
|
23033978 |
2012 |
MENTAL RETARDATION, AUTOSOMAL DOMINANT 6
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders.
|
23160955 |
2012 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The significant associations and interactions were located at the 3' region of GRIN2B suggesting that genetic variation in this part of the gene may be involved in the pathophysiology of schizophrenia.
|
21919190 |
2011 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Variations in the N-methyl-d-aspartate receptor 2B subunit gene (GRIN2B) have been associated with schizophrenia, a psychiatric disorder associated with reduced left-hemispheric language dominance.
|
21827795 |
2011 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The present results support the hypothesis that rare de novo mutations in GRIN2A or GRIN2B can be associated with cases of sporadic SCZ or ASD, just as it has recently been described for the related neurodevelopmental disease intellectual disability.
|
22833210 |
2011 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In the present work, we investigated whether expression of this NR2B-associated trafficking complex might be abnormal in schizophrenia.
|
20347576 |
2010 |
MENTAL RETARDATION, AUTOSOMAL DOMINANT 6
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.
|
20890276 |
2010 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
CTD_human |
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
|
18583979 |
2008 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We found decreased NR1 expression in all three illnesses, decreased NR2A in schizophrenia and major depression, and decreased NR2C in schizophrenia.We found no changes of NR2B or NR2D.
|
18033238 |
2008 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
It is necessary to explain the inconsistency of these results and to clarify the contribution of the GRIN2B gene to schizophrenia.
|
17224684 |
2007 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association analysis of polymorphisms in the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GRIN2B) gene and tardive dyskinesia in schizophrenia.
|
17669510 |
2007 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
LHGDN |
The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder.
|
16549338 |
2006 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the present study, we performed western blot analysis to determine whether protein levels of NMDA receptor subunits (NR1, NR2A, NR2B) and associated PSD proteins (NF-L, PSD95, SAP102) are altered in schizophrenia.
|
16762023 |
2006 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder.
|
16549338 |
2006 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
These findings suggest that the combined effects of the polymorphisms in the GRIN1 and GRIN2B genes might be involved in the etiology of schizophrenia.European Journal of Human Genetics (2005) 13, 807-814. doi:10.1038/sj.ejhg.5201418 Published online 20 April 2005.
|
15841096 |
2005 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray.
|
15841096 |
2005 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that GRIN2B variations might be linked with susceptibility to schizophrenia.
|
15211626 |
2004 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
These results suggest that GRIN2B variations might be linked with susceptibility to schizophrenia.
|
15211626 |
2004 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In the present work, we observed increased expression of NMDA NR2B subunit transcripts, and decreased expression of all three associated postsynaptic density protein transcripts in schizophrenia.
|
15054476 |
2004 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Association analysis of the genetic variants of the N-methyl D-aspartate receptor subunit 2b (NR2b) and treatment-refractory schizophrenia in the Chinese.
|
12824739 |
2003 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
These findings suggest that the T-200G variant causes dysfunction of NMDA receptors consisting of the NR2B subunit and may be involved in the development of schizophrenia.
|
12476325 |
2002 |