Drug abuse
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This preliminary study explored associations among childhood trauma (loss of a parent or sexual abuse in childhood), maternal self-efficacy, and leukocyte gene expression (mRNA) of oxytocin and glucocorticoid receptors (OXTR and NR3C1) in mothers of infants.
|
29580902 |
2019 |
Drug abuse
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, the GR-induced leukocyte response was enhanced in patients with sexual abuse (F = 7.176; p = 0.008).
|
30086534 |
2018 |
Drug abuse
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
NR3C1 mean methylation was higher among women who reported childhood abuse.
|
27620456 |
2016 |
Drug abuse
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
The results indicated a significant positive correlation between NR3C1 methylation status and childhood maltreatment (specifically physical abuse).
|
25048180 |
2014 |
Drug abuse
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We measured methylation levels in selected NR3C1 promoter regions using DNA obtained from lymphocytes in 64 women with BN (32 selected as having a history of severe childhood abuse and 32 selected as having no such history) and 32 comparison women with no ED or history of childhood abuse.
|
23417893 |
2013 |
Drug abuse
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we present DNA methylation profiles spanning 6.5 million base pairs centered at the NR3C1 gene in the hippocampus of humans who experienced abuse as children and nonabused controls.
|
23045659 |
2012 |
Drug abuse
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Interaction of the BcII glucocorticoid receptor polymorphism and childhood abuse in Bulimia Nervosa (BN): relationship to BN and to associated trait manifestations.
|
22088926 |
2012 |
Drug abuse
|
0.100 |
Biomarker
|
group |
BEFREE |
We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14-year-old adolescents (n=4534).
|
20731635 |
2011 |
Drug abuse
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We explored the extent to which childhood abuse (physical or sexual), variants of a main glucocorticoid receptor (GR) polymorphism (Bcl1), or their interaction, differentiated women with and without BN.
|
21093928 |
2011 |
Drug abuse
|
0.100 |
Biomarker
|
group |
BEFREE |
Childhood sexual abuse, its severity and the number of type of maltreatments positively correlated with NR3C1 methylation (P=6.16 × 10(-8), 5.18 × 10(-7) and 1.25 × 10(-9), respectively).
|
22832351 |
2011 |
Drug abuse
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Studies in animal models of early stress and in humans who have experienced childhood trauma or abuse suggest that these events can lead to long-lasting epigenetic changes in the glucocorticoid receptor gene brought about by hypermethylation of a key regulatory component.
|
20585338 |
2010 |
Drug abuse
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We examined epigenetic differences in a neuron-specific glucocorticoid receptor (NR3C1) promoter between postmortem hippocampus obtained from suicide victims with a history of childhood abuse and those from either suicide victims with no childhood abuse or controls.
|
19234457 |
2009 |