High-Grade Squamous Intraepithelial Lesions
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
HPV 16 was found the most common HR-HPV type in ASC-US and LSIL whereas HPV 18 was the most common in HSIL.
|
30880699 |
2019 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Cytological examination revealed 12% of participants had atypical squamous cells of undetermined significance (ASC-US), 8% had low-grade squamous intraepithelial lesions (LSIL), 7% had high-grade squamous intraepithelial lesions (HSIL), and 14% had squamous cell carcinoma (SCC), while 59% of women had a normal cytology.
|
30261268 |
2018 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Ten of the 15 cases were identified as atypical squamous cells - cannot exclude an HSIL (ASC-H) with secondary diagnosis of low-grade squamous intraepithelial lesion (LSIL), while five cases were identified as high-grade squamous intraepithelial lesion (HSIL), and a subsequent biopsy was recommended.
|
29154448 |
2018 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Both AHPV and Cobas were equally sensitive in detecting high-grade SIL in both scenarios of screening and ASC-US or AGC triage but AHPV showed a higher specificity.
|
30368218 |
2018 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Cytological abnormalities were classified as atypical squamous cells of undetermined significance (ASC-US), low-grade(LSIL) or high high-grade squamous intraepithelial lesion (HSIL).
|
29088236 |
2017 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The per 1 log<sub>10</sub> -unit increase in viral load of a group of species 9 non-HPV16 oncogenic types was statistically significantly associated with risk of CIN2/3 for women with a cytologic diagnosis of within normal limits, ASC-US, or LSIL at the first HPV-positive visit but not for those with high-grade SIL.
|
28052328 |
2017 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
There was no difference in the ability of LSIL-H and ASC-H to predict CIN 2+.
|
27245707 |
2017 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
A substantial subset of patients with ASC-H interpretations is associated with an appreciable risk of clinically significant cervical disease. p16/Ki67 dual stain can provide additional valuable information that may lead to higher-quality management of women with ASC-H, especially when initial colposcopy or biopsy results do not show HSIL lesions.
|
28244884 |
2017 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Although patients found to have atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesions (LSILs) on Papanicolaou (Pap) testing are treated conservatively, 5.2% to 18.8% of them progress to high-grade squamous intraepithelial lesions (HSILs).
|
26335500 |
2016 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The HPV-positive rates for ASC-US and ASC-H were similar in 2012 and 2006.
|
25436905 |
2015 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The distribution of Pap smear results was normal (4.7%), atypical squamous cells of uncertain significance (ASCUS) (42.1%), low-grade squamous intraepithelial lesion (26.8%), ASC-H (7.0%), and high-grade squamous intraepithelial lesion (HSIL) (19.5%).
|
24825374 |
2014 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Two women with ASC-US who were HPV DNA negative by the HC-II and positive by the TS-MPG or/and LA assays had lesions that progressed to low-grade squamous intraepithelial and high-grade squamous intraepithelial lesions.
|
23035194 |
2012 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Thirty six of them (37.9%) showed abnormal anal cytology as follows: atypical squamous cells of undetermined significance (ASC-US) in 19 (20.0%), atypical squamous cells but cannot exclude HSIL (ASC-H) in 1 (1.1%), low-grade squamous intraepithelial lesion (LSIL) in 15 (15.8%), and high-grade squamous intraepithelial lesion (HSIL) in 1 (1.1%).
|
22558293 |
2012 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Patients with LSIL-H and HSIL had similar infection rates for low-risk/intermediate-risk HPV genotypes, which were lower than those in LSIL or LSIL and ASC-H combined.
|
22648956 |
2012 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results indicate that HPV triage testing is a reasonable and cost-effective approach for women with ASC-US vaginal Pap results and also a useful option for women with ASC-H vaginal Pap results.
|
22338056 |
2012 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Forty-five patients underwent conization for known lesions ranging from atypical squamous cells of undetermined significance (ASC-US) with high-risk HPV (hr-HPV) to high-grade squamous intraepithelial lesion (H-SIL/CIN2+) or adenocarcinoma.
|
19689463 |
2010 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Liquid-based cytology cases interpreted as high-grade squamous intraepithelial lesion (HSIL); low-grade squamous intraepithelial lesion (LSIL); atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H); and atypical squamous cells of undetermined significance (ASC-US) at Magee-Womens Hospital (Pittsburgh, Pennsylvania) were retrospectively identified for a 36-month period between July 1, 2005, and June 30, 2008, from women 50 years and older who also had hrHPV DNA test results.
|
20670132 |
2010 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Positive rate of high-risk HPV DNA in groups of atypical squamous cells of undetermined significance (ASC-US), atypical squamous cells, cannot exclude high-grade (ASC-H), low-grade squamous intraepithelial lesions and high-grade squamous intraepithelial lesions was 53.7, 53.2, 84.6 and 93.0%, respectively.
|
17355305 |
2007 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The positive predictive value (PPV) of ASC-H for high-grade squamous intraepithelial lesions overall was 32% while PPV of ASC-H with associated HR HPV was 42%.
|
17173297 |
2007 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
HPV-positive rates were determined in cases of low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL), and follow-up rates of cervical intraepithelial neoplasia (CIN) were determined in HPV-positive and -negative cases of atypical squamous cells of unknown significance (ASC-US).
|
17091508 |
2006 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The specificity for HC2 was 8.3% for HSIL, 16.9% for LSIL, and 48.7% for ASC-US; whereas the specificity for p16(INK4a) was 25% in HSIL, 59.1% in LSIL, and 68.4% in ASC-US.
|
17078096 |
2006 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Of the remaining 139 (52.3%) cases, 86 (62%) had follow-up Pap Tests, of which 57 (66.3%) were negative, 15 (17.4%) were ASC-US, 12 (15%) were low-grade squamous intraepithelial lesions, and 2 (2.3%) were high-grade squamous intraepithelial lesions; 53 (38.1%) were lost to follow-up.
|
17041955 |
2006 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
One hundred seven cases, including 23 negative cases, 34 with low-grade squamous intraepithelial lesion (LSIL), 16 with high-grade squamous intraepithelial lesion (HSIL), 29 with atypical squamous cells of uncertain significance (ASC-US), and 5 cases with ASC suspicious for HSIL (ASC-H), were evaluated for both p16 expression and HPV DNA.
|
15584047 |
2005 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Furthermore, HPV was detected in 56% of ASC-US and 71% of ASC-H cases.
|
15086283 |
2004 |
High-Grade Squamous Intraepithelial Lesions
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The cumulative incidence for a Pap test interpreted as atypical squamous cells or more severe (>or= ASC) was 16.8% (95% confidence interval [CI] = 15.0-18.6%), 6.4% (95% CI = 5.2-7.6%) for low-grade squamous intraepithelial lesions or more severe, and 2.2% (95% CI = 1.5-2.9%) for high-grade squamous intraepithelial lesions or more severe.
|
12412168 |
2002 |