GRM3, glutamate metabotropic receptor 3, 2913

N. diseases: 79; N. variants: 13
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.320 Biomarker disease BEFREE Our data show that oncogenic GRM3 variants dysregulate cAMP signaling, a heretofore unknown role for these oncogenes. cAMP signaling has been implicated in melanoma progression and drug resistance, and our data show that oncogenic properties of GRM3 could be mediated, at least in part, by alterations in cAMP signaling. 28646617 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.320 Biomarker disease CTD_human Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. 22842228 2012
CUI: C0025202
Disease: melanoma
melanoma 		0.320 Biomarker disease CTD_human Melanoma cells expressing mutant GRM3 had reduced cell growth and cellular migration after short hairpin RNA-mediated knockdown of GRM3 or treatment with a selective MEK inhibitor, AZD-6244, which is currently being used in phase 2 clinical trials. 21946352 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.320 GeneticVariation disease BEFREE Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma. 21946352 2011