Neuralgia
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We successfully elucidated the degree of pain-sensing behavior using the neuropathic pain-specific pattern of the mGluR5 availability.
|
29990583 |
2019 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Metabotropic Glutamate Receptor 5 and 8 Modulate the Ameliorative Effect of Ultramicronized Palmitoylethanolamide on Cognitive Decline Associated with Neuropathic Pain.
|
30970677 |
2019 |
Neuralgia
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Collectively, the results in this study indicated nerve injury diminishes spinal Hes1-dependent suppression of CDK9-dependent RNAPII phosphorylation on the mGluR5 promoter that possibly enhances mGluR5 transcription/expression for neuropathic pain development.
|
31454988 |
2019 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Publisher Correction: Upregulation of prefrontal metabotropic glutamate receptor 5 mediates neuropathic pain and negative mood symptoms after spinal nerve injury in rats.
|
29880903 |
2018 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Interestingly, 2% moringin cream treatment was found to modulate the expression of voltage-gated ion channels (results focused on P2X7, Nav 1.7, Nav 1.8 KV4.2, and α2δ-1) as well as metabotropic glutamate receptors (mGluR5 and xCT) involved in neuropathic pain initiation and maintenance.
|
28741431 |
2018 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Publisher Correction: Upregulation of prefrontal metabotropic glutamate receptor 5 mediates neuropathic pain and negative mood symptoms after spinal nerve injury in rats.
|
29410506 |
2018 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
This suggests that the pharmacological modulation of mGluR5 could be a new approach to reduce both cephalic and extra-cephalic neuropathic pain.
|
28533177 |
2017 |
Neuralgia
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
A pharmacological blockade of upregulated mGluR5 in the PrL ameliorated the negative symptoms including tactile hypersensitivity and depressive-like behavior, which relieved the subjects from the unpleasant state of chronic neuropathic pain condition.
|
28851991 |
2017 |
Neuralgia
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, the expressions of metabotropic glutamate receptor (mGluR1) and mGluR5, which play a key role in central sensitization and neuropathic pain, and H3 acetylation levels at Grm1/5 (encoding mGluR1/5) promoter regions were increased in diabetic neuropathic pain rats.
|
27749604 |
2017 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Our findings suggest that paclitaxel-induced painful neuropathy is associated with increased presynaptic mGluR5 activity at the spinal cord level, which serves as upstream signaling for PKC-mediated tonic activation of NMDARs. mGluR5 is therefore a promising target for reducing chemotherapy-induced neuropathic pain.
|
29074619 |
2017 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice.
|
28891868 |
2017 |
Neuralgia
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
These findings suggest that increased mGluR5 expression on primary afferent neurons contributes to increased glutamatergic input to spinal dorsal horn neurons and nociceptive transmission in diabetic neuropathic pain.
|
19840219 |
2010 |