GRM8, glutamate metabotropic receptor 8, 2918

N. diseases: 56; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 GeneticVariation disease BEFREE Our findings indicate that rs712723 in GRM8 may play an important role in the pathogenesis of SCZ. 30288643 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease BEFREE We demonstrated the genetic association of GRM7 and GRM8 with SCZ and MDD in the Han Chinese population. 26655190 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease BEFREE This study indicates that the GRM8 gene may play an important role in the pathogenesis of schizophrenia. 25588301 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease PSYGENET These data provide a potential role for mGluR8 in anxiety and suggest that mGluR8 may not be a therapeutic target for schizophrenia. 17434465 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease BEFREE These data provide a potential role for mGluR8 in anxiety and suggest that mGluR8 may not be a therapeutic target for schizophrenia. 17434465 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease PSYGENET Thus, we conclude that at least one susceptibility locus for schizophrenia is located within the GRM8 region in Japanese. 15211621 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 GeneticVariation disease BEFREE Thus, we conclude that at least one susceptibility locus for schizophrenia is located within the GRM8 region in Japanese. 15211621 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 GeneticVariation disease BEFREE Both variants, present at high frequencies, failed to demonstrate any significant association with schizophrenia (mGluR7 [Tyr433Phe] allele: P=0.33; genotype: P=0.63; mGluR8 [2846-C/T] allele: P=0.72; genotype: P=0.63). 11163549 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease PSYGENET Both variants, present at high frequencies, failed to demonstrate any significant association with schizophrenia (mGluR7 [Tyr433Phe] allele: P=0.33; genotype: P=0.63; mGluR8 [2846-C/T] allele: P=0.72; genotype: P=0.63). 11163549 2001
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 Biomarker disease BEFREE Taken together, these findings demonstrate that mGluR8-targeted pharmacotherapies may be beneficial for the treatment of anxiety and alcoholism. 28322866 2017
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 Biomarker disease BEFREE These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence. 25978827 2015
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 Biomarker disease BEFREE Our results suggest that variation in GRM8 may be involved in modulating event-related theta oscillations during information processing and also in vulnerability to alcoholism. 18618593 2009
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 Biomarker disease PSYGENET Our results suggest that variation in GRM8 may be involved in modulating event-related theta oscillations during information processing and also in vulnerability to alcoholism. 18618593 2009
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.320 Biomarker disease BEFREE Further, CNVs mapped to glutamate receptor genes (GRM1, GRM5, GRM7 and GRM8) have been implicated in the aetiology of the disorder and overlap with bioinformatic predictions based on ADHD GWAS SNP data regarding enriched pathways. 25600112 2015
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.320 Biomarker disease BEFREE The aim of the present study was to investigate if copy number variants (CNVs) in GRM1, GRM5, and GRM8 genes are overrepresented in ADHD subjects. 24985920 2014
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.320 Biomarker disease CTD_human Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. 22138692 2011
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.310 Biomarker disease LHGDN Therefore, both RELN and GRM8 genes are considered to be not only the positional but also the functional candidate genes to autism for association research. 17955477 2008
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.310 GeneticVariation disease BEFREE Therefore, both RELN and GRM8 genes are considered to be not only the positional but also the functional candidate genes to autism for association research. 17955477 2008
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.310 Biomarker group BEFREE These data provide a potential role for mGluR8 in anxiety and suggest that mGluR8 may not be a therapeutic target for schizophrenia. 17434465 2007
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.310 Biomarker group CTD_human These data provide a potential role for mGluR8 in anxiety and suggest that mGluR8 may not be a therapeutic target for schizophrenia. 17434465 2007
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.310 Biomarker disease CTD_human The metabotropic glutamate receptor 8 gene at 7q31: partial duplication and possible association with autism. 12676915 2003
CUI: C0001957
Disease: Alcohol Withdrawal Delirium
Alcohol Withdrawal Delirium 		0.310 GeneticVariation disease BEFREE No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals. 11912074 2002
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.300 Biomarker disease CTD_human Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. 22941189 2012
CUI: C0041671
Disease: Attention Deficit Disorder
Attention Deficit Disorder 		0.300 Biomarker disease CTD_human Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. 22138692 2011
CUI: C1321905
Disease: Minimal Brain Dysfunction
Minimal Brain Dysfunction 		0.300 Biomarker disease CTD_human Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. 22138692 2011