|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The underlying mechanism for this transformation by ttIL-12 treatment was induction of expression of CXCL9 and reduction of expression of CXCL2 and CCL22 in tumors.
|
31208461 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, tumors with higher CXCL2 expression included significantly more numbers of multiple tumors than the lower expression group.
|
30564899 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the validation cohort, however, only the changes in the plasma levels of CXCL2 and MMP2 after treatment were associated with PFS (p = 0.003 and p = 0.006, respectively), and these changes were maintained during the course of anti-PD-1 therapy in patients who showed better clinical outcomes, even in those with tumor pseudoprogression.
|
30307035 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Addition of MMM to colon tumors <i>in vivo</i> significantly enhances tumor growth in control tumors and restores tumor growth in the presence of MK2 inhibition.
|
30298062 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Chemokine (C-X-C motif) ligand 1 and CXCL2 produced by tumor promote the generation of monocytic myeloid-derived suppressor cells.
|
30259595 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor cell growth in Emilin2 null mice was impaired as well as the expression of MIP-2.
|
29483644 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In animal studies, we found that overexpressing CXCL2 by lentivirus also apparently inhibited the size and weight of subcutaneous tumours in nude mice.
|
30293547 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, we showed that MDSC recruitment to the primary tumor and metastatic sites occurs via direct ΔNp63-dependent activation of the chemokines CXCL2 and CCL22.
|
30295647 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Snail knockdown reduces the expression of CXCR2 ligands (CXCL1 and CXCL2), chemokines that attract MDSCs to the tumor via CXCR2.
|
29703902 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Analysis of immune cells revealed that CXCR2 ligands (CXCL1, CXCL 2 and CXCL5) expressed by TNFα-activated MSCs efficiently recruited CXCR2<sup>+</sup> neutrophils into tumor.
|
27375023 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CXCL2 secreted from TAM-like macrophages plays an important role in tumour invasiveness.
|
27425378 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Using a genetically engineered mouse model of PDA, we found that tumor and stromal cells differentially expressed CXCR2 ligands, with Cxcl5 high in tumor and Cxcl2 high in stroma.
|
27737879 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
High GROβ cytoplasm staining was significantly associated with patients' age (P = 0.043) and tumor location (P = 0.014), while high GROβ nucleus staining was significantly associated with mitotic index (P = 0.034), tumor location (P = 0.049), and AFIP-Miettinen risk classification (P = 0.048).
|
25944970 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results indicated that LPS upregulated a series of pro-inflammatory cytokines and theophylline significantly attenuated the expression levels of pro-inflammatory cytokines tumor necrosis factor‑α, macrophage inflammatory protein (MIP)-1α and MIP-2, and markedly elevated the production of tumor growth factor (TGF)-β family members TGF-β1, TGF-β2 and TGF-β3, which are anti‑inflammatory cytokines.
|
24788885 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MTX stimulated the production of CXCL8 by human cancer cells in vitro and that of Cxcl2 by murine tumors in vivo.
|
23787997 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Evidence of biological HP-NAP activity was observed 24 hours after treatment with neutrophil infiltration in tumors and an increase of proinflammatory cytokines such as tumor necrosis factor (TNF)-α and MIP2-α in the systemic circulation.
|
23817216 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To study the effect of localised secretion of chemokines on tumour growth, the genes for human (hu) interleukin 8 (IL-8), hu-MCP-1 (MCAF), hu-MIP-1 alpha (LD78), murine (mu)-MCP-1 (JE), mu-MIP-1 alpha or mu-MIP-2 were introduced, via mammalian expression vectors, into Chinese hamster ovary (CHO) cells, and the ability of transfected cells to form tumours in vivo was evaluated.
|
7669585 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The incidence of the tumor reached about 40% when the rats were 12 months old. mRNAs of both pX and host genes Gro and MIP-2, which are granulocyte chemoattractants of the interleukin 8 family, were highly expressed in the tumor tissue.
|
7780962 |
1995 |