GSK3B, glycogen synthase kinase 3 beta, 2932

N. diseases: 393; N. variants: 25
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease LHGDN Because our samples provided quite high power, these results indicate that GSK3B may not play a major role in Japanese schizophrenia. 15719395 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE Because our samples provided quite high power, these results indicate that GSK3B may not play a major role in Japanese schizophrenia. 15719395 2005
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 GeneticVariation disease BEFREE GSK3B polymorphisms alter transcription and splicing in Parkinson's disease. 16315267 2005
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 GeneticVariation disease LHGDN GSK3B polymorphisms alter transcription and splicing in Parkinson's disease. 16315267 2005
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.050 Biomarker disease LHGDN GSK3 and PKB/Akt are associated with integrin-mediated regulation of PTHrP, IL-6 and IL-8 expression in FG pancreatic cancer cells. 15609321 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 Biomarker disease BEFREE In conclusion, these results suggest that the GSK-3 beta is not associated with the development of schizophrenia and bipolar disorder in Korean population. 16289845 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease LHGDN Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia. 16987250 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE In conclusion, these results suggest that the GSK-3 beta is not associated with the development of schizophrenia and bipolar disorder in Korean population. 16289845 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.560 Therapeutic disease RGD Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3 beta. 16565311 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.560 Biomarker disease CTD_human PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway. 16716347 2006
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker disease CTD_human PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. 16421604 2006
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.340 Biomarker group CTD_human PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. 16421604 2006
CUI: C0003865
Disease: Arthritis, Adjuvant-Induced
Arthritis, Adjuvant-Induced 		0.300 Biomarker disease CTD_human IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. 16713974 2006
CUI: C0031154
Disease: Peritonitis
Peritonitis 		0.300 Biomarker disease CTD_human IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. 16713974 2006
CUI: C0971858
Disease: Arthritis, Collagen-Induced
Arthritis, Collagen-Induced 		0.300 Biomarker disease CTD_human IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. 16713974 2006
CUI: C0993582
Disease: Arthritis, Experimental
Arthritis, Experimental 		0.300 Biomarker disease CTD_human IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. 16713974 2006
CUI: C1449646
Disease: Primary Peritonitis
Primary Peritonitis 		0.300 Biomarker disease CTD_human IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. 16713974 2006
CUI: C1449647
Disease: Secondary Peritonitis
Secondary Peritonitis 		0.300 Biomarker disease CTD_human IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. 16713974 2006
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.050 AlteredExpression disease LHGDN Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation. 16951223 2006
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.040 AlteredExpression disease LHGDN Glycogen synthase kinase-3beta positively regulates the proliferation of human ovarian cancer cells. 16788573 2006
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.020 AlteredExpression group LHGDN Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation. 16951223 2006
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.010 AlteredExpression group LHGDN Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells. 16371352 2006
CUI: C0333641
Disease: Atrophic
Atrophic 		0.010 Biomarker phenotype LHGDN Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy. 16916907 2006
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.700 Biomarker disease LHGDN Intracellular domains of amyloid precursor-like protein 2 interact with CP2 transcription factor in the nucleus and induce glycogen synthase kinase-3beta expression. 16645641 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.700 Biomarker disease CTD_human Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden. 17409235 2007