GSK3B, glycogen synthase kinase 3 beta, 2932

N. diseases: 393; N. variants: 25
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.700 AlteredExpression disease LHGDN GSK3beta activity modifies the localization and function of presenilin 1. 17389597 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 Biomarker disease BEFREE The kinase glycogen synthase kinase 3 beta (GSK3beta) is considered as an interesting target of lithium, the classical drug used in BD. 16733521 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 GeneticVariation disease LHGDN Further evidence on the lack of association between glycogen synthase kinase 3beta gene polymorphisms and bipolar disorder. 17621172 2007
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.580 GeneticVariation disease BEFREE Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism. 17628506 2007
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.580 Biomarker disease PSYGENET Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism. 17628506 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.570 Biomarker disease PSYGENET Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism. 17628506 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.570 GeneticVariation disease BEFREE Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism. 17628506 2007
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker phenotype CTD_human Inhibition of glycogen synthase kinase 3beta during heart failure is protective. 17901358 2007
CUI: C0018801
Disease: Heart failure
Heart failure 		0.320 Biomarker disease CTD_human Inhibition of glycogen synthase kinase 3beta during heart failure is protective. 17901358 2007
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.320 Biomarker disease CTD_human Inhibition of glycogen synthase kinase 3beta during heart failure is protective. 17901358 2007
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.320 Biomarker disease CTD_human Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden. 17409235 2007
CUI: C0276496
Disease: Familial Alzheimer Disease (FAD)
Familial Alzheimer Disease (FAD) 		0.310 Biomarker disease CTD_human Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden. 17409235 2007
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.300 Biomarker disease CTD_human Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden. 17409235 2007
CUI: C0023212
Disease: Left-Sided Heart Failure
Left-Sided Heart Failure 		0.300 Biomarker disease CTD_human Inhibition of glycogen synthase kinase 3beta during heart failure is protective. 17901358 2007
CUI: C0235527
Disease: Heart Failure, Right-Sided
Heart Failure, Right-Sided 		0.300 Biomarker disease CTD_human Inhibition of glycogen synthase kinase 3beta during heart failure is protective. 17901358 2007
CUI: C0546126
Disease: Acute Confusional Senile Dementia
Acute Confusional Senile Dementia 		0.300 Biomarker disease CTD_human Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden. 17409235 2007
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset 		0.300 Biomarker disease CTD_human Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden. 17409235 2007
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.300 Biomarker disease CTD_human Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden. 17409235 2007
CUI: C1383860
Disease: Cardiac Hypertrophy
Cardiac Hypertrophy 		0.300 Biomarker phenotype CTD_human Inhibition of glycogen synthase kinase 3beta during heart failure is protective. 17901358 2007
CUI: C1959583
Disease: Myocardial Failure
Myocardial Failure 		0.300 Biomarker disease CTD_human Inhibition of glycogen synthase kinase 3beta during heart failure is protective. 17901358 2007
CUI: C1961112
Disease: Heart Decompensation
Heart Decompensation 		0.300 Biomarker phenotype CTD_human Inhibition of glycogen synthase kinase 3beta during heart failure is protective. 17901358 2007
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.070 GeneticVariation phenotype BEFREE Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism. 17628506 2007
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.050 Biomarker disease LHGDN Primers on molecular pathways. The glycogen synthase kinase-3beta. 17912008 2007
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.040 GeneticVariation disease BEFREE In each racial group, we observed that a specific, although different, GSK3B haplotype was associated with increased frequency of PCOS, suggesting that GSK3beta contributes to the pathophysiology and inherited basis of PCOS. 17270183 2007
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.020 GeneticVariation group LHGDN Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer. 17241872 2007