Male infertility
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Our meta-analysis supports that the GSTM1/GSTT1 null genotype might contribute to individual susceptibility to male infertility in Chinese populations.
|
30732132 |
2019 |
Male infertility
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our findings also underrate the significance of the effect of GSTM1 and/or GSTT1 (especially the former) in modulating the risk of male infertility in males from Sichuan, Southwest China.
|
25532576 |
2016 |
Male infertility
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Genotype combinations GSTP1 105II/GSTT1 del (G1), GSTM1 del/GSTT1 del (G2) and GSTM1 + /GSTT1 del (G3) were associated with decreased risk of male infertility (P ≤ 0.003), whereas a genotype combination GSTP1 105IV/GSTT1 + (G4) was associated with increased disease risk (P = 0.001).
|
25348056 |
2015 |
Male infertility
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Glutathione S-transferase Mu-1 gene polymorphism in Egyptian patients with idiopathic male infertility.
|
25130880 |
2015 |
Male infertility
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The results suggested that null genotypes of GSTM1 and GSTT1 are associated with spermatogenesis impairment and may contribute to susceptibility to spermatogenesis impairment and male infertility in Chinese population.
|
23311983 |
2013 |
Male infertility
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Overall, a significant association was seen between GSTM1 (OR=1.20, 95 % CI=1.02-1.40, P(heterogeneity) =0.000, P=0.027) genotypes and male infertility.
|
23239128 |
2013 |
Male infertility
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Further studies of GSTM1 and GSTT1 with their biological functions are needed to understand the role of these genes in the development of male infertility.
|
23877133 |
2013 |
Male infertility
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These results indicated that the null genotype of the GSTM1 gene might contribute to the susceptibility of male infertility, whereas the null genotype of the GSTT1 gene may be a genetic susceptibility factor of male infertility for the Chinese.
|
23631429 |
2013 |
Male infertility
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In conclusion, these results support that the GSTM1 null genotype mainly contributes to idiopathic male infertility susceptibility, particularly to OAT.
|
23026209 |
2012 |
Male infertility
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These results demonstrated that amongst populations studied to date, GSTM1 and GSTT1 null genotypes are associated with strong and modest increase in the risk of male infertility, respectively.
|
22903474 |
2012 |
Male infertility
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In subgroup analysis of Caucasians, there was also an obvious association between GSTM1 null genotype and increased risk of male infertility (OR = 1.51, 95%CI 1.11-2.05, P = 0.006).
|
22622525 |
2012 |
Male infertility
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We observed an association between male infertility and the GSTM1 and GSTT1 null deletion, but not with the CYP1A1 polymorphism in North Iranian men with idiopathic infertility.
|
21775774 |
2012 |
Male infertility
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The study showed statistically significant protective association of GSTT1 null genotype with human male infertility (odds ratio [OR]: 0.3, 95% confidence interval [CI] 0.143-0.9966, P = .048) but not with GSTM1 null genotype (OR: 0.66, 95% CI 0.3653-1.2234, P = .19).
|
22383780 |
2012 |
Male infertility
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The aim of this study was to examine whether an association exists between glutathione S-transferase Mu-1 (GSTM1) gene polymorphism and idiopathic male infertility.
|
20629642 |
2010 |
Male infertility
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
MTHFR C677T polymorphism, GSTM1 deletion and male infertility: a possible suggestion of a gene-gene interaction?
|
16484136 |
2006 |
Male infertility
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Polymorphisms of glutathione S-transferase M1 and male infertility in Taiwanese patients with varicocele.
|
11870126 |
2002 |