Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was a slight, but not statistically significant, increase of the risk of colon cancer for the GSTM1*0 and GSTT1*0 variants.
|
30106268 |
2018 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analyzed 20 germline polymorphisms in 10 genes (TS, MTHFR, ERCC1, XPD, XRCC1, ABCC2, AGXT, GSTP1, GSTT1 and GSTM1) from prospectively enrolled 292 Korean patients treated with adjuvant oxaliplatin plus leucovorin plus 5-fluorouracil (FOLFOX) for colon cancer.
|
23314736 |
2013 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The combined GSTM1 null and GSTP1 114Val allele also revealed an increased risk for either colon cancer (OR=4.69; 95% CI, 0.84-23.87) or rectal cancer (OR=5.68; 95% CI, 1.79-22.16).
|
20688591 |
2011 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTM1 homozygous null genotype was associated with an increased risk of colon cancer, especially in females and in younger patients.
|
19443391 |
2009 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTT1 and GSTM1 polymorphisms may be weakly related to colon cancer risk and there may be racial differences in gene-smoking interactions.
|
16596290 |
2006 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Having GSTM1 present, a CYP1A1 variant allele, and the rapid-acetylator NAT2 imputed phenotype was associated with increased risk of colon cancer (odds ratio = 1.7, 95% confidence interval: 1.2, 2.3).
|
15496536 |
2004 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
If pooling studies were based on the genotyping method, the overall odds ratio of colon cancer risk associated with the GSTM1 deficiency showed no difference.
|
14523342 |
2003 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Individuals with the GSTM1 null genotype showed colon cancer onset at earlier age (58.8 +/- 1.8 vs. 63.5 +/- 1.6 years; Mann-Whitney U, p = 0.047).
|
14601045 |
2003 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, among individuals with both GSTM1 and T1 null genotypes, we observed a 57% reduction in risk among high versus low consumers of ITC (OR 0.43, 95% CI 0.20-0.96), in particular for colon cancer (OR 0.31, 0.12-0.84).
|
12507929 |
2002 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Epidemiological studies have linked consumption of broccoli to a reduced risk of colon cancer in individuals with the glutathione S-transferase M1 (GSTM1) null genotype.
|
11133820 |
2000 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Western diet, family history of colorectal cancer, NAT2, GSTM-1 and risk of colon cancer.
|
10680724 |
2000 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Individuals who are GSTM1 null have increased susceptibility to lung and colon cancer.
|
10868693 |
2000 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among younger individuals who were GSTM-1 present (relative to those with GSTM-1 null), we observed an inverse association with colon cancer regardless of level of cruciferous vegetable intake (OR 0.74 95% CI 0.30-1.79 for no intake; OR 0.44 95% CI 0.21-0.92 for <4 servings/week; and OR 0.
|
10925368 |
2000 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No significant associations with colon cancer risk were observed for different NAT2 and GSTM1 gene variants.
|
9950235 |
1999 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Current cigarette smokers with GSTM1 null genotype were not at an increased risk of colon cancer (OR = 1.2; 95% CI, 0.3-4.2) compared with current smokers without the null genotype; for the GSTT1 null genotype this OR was 1.1 = 95% CI (0.3-4.7).
|
9829708 |
1998 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Neither NAT2 nor GSTM-1 polymorphisms were significantly associated with colon cancer, except among older women, in whom the intermediate/rapid imputed phenotype was associated with increased risk of colon cancer [odds ratio (OR) = 1.4, 95% confidence interval (CI) = 1.0-1.81.
|
9865425 |
1998 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using PCR to identify the GSTM1 genotype, we found the frequency of GSTM1- in colon cancer (n = 19) and control group (n = 23) was 36.8% and 26.1%, respectively (p > 0.05, chi 2-test).
|
9003527 |
1996 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Some studies have reported an association of the GSTM1-null genotype with the risk of smoking-related cancers, such as lung, bladder, and colon cancer.
|
8959321 |
1996 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Glutathione S-transferase M1 and T1 polymorphisms: susceptibility to colon cancer and age of onset.
|
7614702 |
1995 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer.
|
8403204 |
1993 |