|
Acute myocardial infarction
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A significant protective effect of GSTT1 null and GSTP1 Val genotype against disease was observed in patients with AMI although protection was limited to nonsmokers.
|
21389716 |
2011 |
|
Acute on chronic hepatitis B
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In acute-on-chronic hepatitis B liver failure group, nonsurvivors showed significantly higher GSTP1 methylation levels (P < 0.05) than survivors.
|
26040771 |
2015 |
|
Acute on chronic hepatitis B
|
0.030 |
Biomarker
|
disease |
BEFREE |
Promoter methylation of glutathione-S-transferase P1 (GSTP1) may be involved in liver damage caused by oxidative stress in acute-on-chronic hepatitis B-induced liver failure (ACHBLF).
|
21692937 |
2011 |
|
Acute on chronic hepatitis B
|
0.030 |
PosttranslationalModification
|
disease |
BEFREE |
Aberrant GSTP1 promoter methylation predicts poor prognosis of acute-on-chronic hepatitis B pre-liver failure.
|
28676943 |
2018 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that variations in GSTM1, GSTP1, and CASP9 may influence risk for AP.
|
27984487 |
2017 |
|
Acute Promyelocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
GSTP1 Ile105/Val105 and Val105/Val105 genotypes showed no increase in the risk of APL (OR= 0.94; 95% CI: 0.52-1.67 and OR= 1.12; 95% CI: 0.48-2.60, respectively).
|
21875282 |
2011 |
|
Acute-On-Chronic Liver Failure
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
No differences in standard liver function tests were found in patients with acute-on-chronic liver failure with and without GSTP1 promoter methylation although the levels of total bilirubin were greater in those with methylation.
|
21692937 |
2011 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Low levels of GSTA1 and GSTP1 in HGPIN and adenocarcinoma suggest a broad lack of detoxification activity in these cells, which may be associated with carcinogenesis in the prostate.
|
11550208 |
2001 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In adenocarcinoma, a strong association (P < 0.00001) between GSTP1 promoter hypermethylation and loss of GSTpi expression was observed; however, this trend was not retained in prostatic intraepithelial neoplasia or BPH lesions.
|
12010858 |
2002 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma.
|
15526353 |
2004 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The median ratios of MSP-amplified GSTP1 to MYOD1 in the prospectively collected sextant biopsy samples were 410.6 for the patients with adenocarcinoma and 0.0 for the patients with no evidence of adenocarcinoma (P< .001).
|
11717336 |
2001 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
All ten patients diagnosed with adenocarcinoma (100%) and four of six patients with prostatic intraepithelial neoplasia (67%), but none of ten patients with benign hyperplasia (0%), exhibited GSTP1 promoter hypermethylation in at least one out of six biopsy washings.
|
11857497 |
2002 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Because not all PIA cells are positive for GSTP1 protein, we hypothesized that some of the cells within these regions acquire GSTP1 CpG island hypermethylation, increasing the chance of progression to high-grade PIN and/or adenocarcinoma.
|
12937133 |
2003 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
LHGDN |
GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas.
|
17646057 |
2007 |
|
Adenocarcinoma
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Our major findings are a) methylation status of any single gene was largely independent of methylation status of other genes; b) the rates of methylation of p16 and APC and the mean Methylation Index (MI), a reflection of the overall methylation status, were significantly higher in ever smokers than in never smokers; c) the mean MI of tumors arising in former smokers was significantly lower than the mean of current smokers; d) the methylation rates of APC, CDH13 and RARbeta were significantly higher in adenocarcinomas than in squamous cell carcinomas; e) methylation rates of MGMT and GSTP1 were significantly higher in the USA and Australian cases than in those from Japan and Taiwan; and (f) no significant gender-related differences in methylation patterns were noted.
|
12455028 |
2003 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In presented case-control study we investigate the incidence of polymorphism of GSTT1, GSTM1, GSTP1 genes and their combinations as possible predictive factors for identification of individuals with increased risk of formation and development of adenocarcinoma (AC) and squamous cell carcinoma (SCC) of lung in Slovak population.
|
22248273 |
2012 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this case-control study (consisting of 389 Caucasian lung cancer patients, including 151 adenocarcinomas (ACs) and 172 squamous cell carcinomas (SCCs), and 353 hospital control subjects without malignant disease, genotype frequencies for GSTM1, GSTM3, GSTP1 and GSTT1 were determined by polymerase chain reaction (PCR)/ restriction fragment length polymorphism (RFLP)-based methods.
|
11740339 |
2001 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
GSTP1 G allele or GG genotype is not a biomarker to be associated with the susceptibility of adenocarcinomas of lung cancer.
|
23736019 |
2013 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Expression of glutathione s-transferase pi in benign mucosa, Barrett's metaplasia, and adenocarcinoma of the esophagus.
|
12112555 |
2002 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Whereas abundant enzyme polypeptide expression was evident in all normal prostatic tissues, all samples of high-grade PIN and adenocarcinoma were completely devoid of GSTP1.
|
9641498 |
1998 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Low levels of GSTA1 and GSTP1 in HGPIN and adenocarcinoma suggest a broad lack of detoxification activity in these cells, which may be associated with carcinogenesis in the prostate.
|
11550208 |
2001 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The top associated disease identified by IPA was adenocarcinoma; however, the cAMP response element-binding protein (CREB)-, histone deacetylase 2 (HDAC2)-, glutathione S-transferase pi (GSTP1)- and polyubiquitin-C (UBC)-related pathways showed significantly altered methylation profiles based on the canonical pathway and network analyses.
|
29344347 |
2018 |
|
Adenocarcinoma Of Esophagus
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Occurrence of the polymorphic GSTP1b variant in the GSTP1 gene resulted in a significantly lower GST enzyme activity (P < 0.05), and GSTP1b was found significantly more often in patients with Barrett's epithelium (70%; P < 0.001) and patients with esophageal adenocarcinoma (76%; P = 0.005), as compared to healthy blood donors (41%).
|
9973204 |
1999 |
|
Adenocarcinoma Of Esophagus
|
0.020 |
Biomarker
|
disease |
BEFREE |
We conclude that polymorphisms of GSTP1 and mEH may be implicated in individual susceptibility to esophageal adenocarcinoma, possibly as a result of increased Phase I activation (mEH) and impaired Phase II detoxification (GSTP1).
|
12670526 |
2003 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Although separate GSTM1 and GSTP1 polymorphisms were not statistically related to lung AC, the combination of GSTM1 null and GSTP1 Val was significantly associated with an elevated lung AC risk (OR=2.4, 95% CI 1.1-5.1).
|
14607333 |
2003 |