Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE This study reveals a new role of ZDHHC8-cdc42-palm molecular pathway in postsynaptic structural plasticity and provides new evidence in favor of the dysconnectivity hypothesis for schizophrenia. 27365300 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease PSYGENET ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia. 23403413 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia. 23403413 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease PSYGENET We investigated the association of the ZDHHC8 gene locus with schizophrenia using meta-analytic techniques, combining all published data up to May 2009 and focusing on 10 independent studies from six published references covering 2,894 cases, 2,932 controls and 1,225 parent-offspring trios. 20661937 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease PSYGENET The results of the present study provide the first evidence that ZDHHC8 on the 22q11 locus might have influence on SPEM function of schizophrenia patients in a Korean population and may provide a new clue for understanding differential effects of candidate genes in schizophrenia. 20468065 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE We investigated the association of the ZDHHC8 gene locus with schizophrenia using meta-analytic techniques, combining all published data up to May 2009 and focusing on 10 independent studies from six published references covering 2,894 cases, 2,932 controls and 1,225 parent-offspring trios. 20661937 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE The results of the present study provide the first evidence that ZDHHC8 on the 22q11 locus might have influence on SPEM function of schizophrenia patients in a Korean population and may provide a new clue for understanding differential effects of candidate genes in schizophrenia. 20468065 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE For further support from within the Han Chinese ethnic group, we selected two single nucleotide polymorphisms (SNP) located at the distal 5'-end (rs1633445; intron 10 of HpaII tiny fragments locus 9C, HTF9C) and the intron 4 (rs175174) of ZDHHC8 gene to test if these were associated with schizophrenia in a study sample of Taiwan. 18075473 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease PSYGENET For further support from within the Han Chinese ethnic group, we selected two single nucleotide polymorphisms (SNP) located at the distal 5'-end (rs1633445; intron 10 of HpaII tiny fragments locus 9C, HTF9C) and the intron 4 (rs175174) of ZDHHC8 gene to test if these were associated with schizophrenia in a study sample of Taiwan. 18075473 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE We selected four putative risk variants, residing within these genes, ProDH 1945, ProDH 2026, COMT ValMet and ZDHHC8 rs175174, and studied these in a large family-based schizophrenia association sample of European origin (488 Bulgarian parent-offspring trios). 16860541 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease PSYGENET We selected four putative risk variants, residing within these genes, ProDH 1945, ProDH 2026, COMT ValMet and ZDHHC8 rs175174, and studied these in a large family-based schizophrenia association sample of European origin (488 Bulgarian parent-offspring trios). 16860541 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE The findings on rs175174 at ZDHHC8 are still far from being conclusive, but evidence for sexual dimorphism is moderate, and our data do not support a significant genetic contribution of rs175174 to the aetiopathogenesis of schizophrenia. 16225675 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples. 15992527 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE Because our sample size provided quite high power, ZDHHC8 may not play a major role in Japanese schizophrenia. 15631889 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE These data suggest that the ZDHHC8 gene may not be associated with susceptibility to BPD or schizophrenia, at least in a Japanese population. 16150541 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease RGD The genetic association database. 15118671 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease BEFREE Systematic examination of individual genes from the 1.5 Mb critical region has identified so far the PRODH and ZDHHC8 as strong candidate schizophrenia susceptibility genes from this locus. 15582150 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 GeneticVariation disease BEFREE Our results provided compelling supportive evidence for association of the variants within the ZDHHC8 locus with schizophrenia but revealed different risk allele at SNP rs175174. 15489219 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 Biomarker disease BEFREE The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia. 16150541 2005
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.010 Biomarker disease BEFREE We first found increased ZDHHC8 expression in the brains of temporal lobe epilepsy (TLE) patients, similar to that observed in chronic epileptic mice, strongly suggesting that ZDHHC8 is correlated with human epilepsy. 30038264 2018
CUI: C0014556
Disease: Epilepsy, Temporal Lobe
Epilepsy, Temporal Lobe 		0.010 Biomarker disease BEFREE We first found increased ZDHHC8 expression in the brains of temporal lobe epilepsy (TLE) patients, similar to that observed in chronic epileptic mice, strongly suggesting that ZDHHC8 is correlated with human epilepsy. 30038264 2018
CUI: C0036572
Disease: Seizures
Seizures 		0.010 AlteredExpression phenotype BEFREE ZDHHC8 levels were consistent with seizure susceptibility in induced mice with SRSs. 30038264 2018
CUI: C4551903
Disease: Total anomalous pulmonary venous return
Total anomalous pulmonary venous return 		0.010 AlteredExpression disease BEFREE We identified 42 rare variants of 7 genes (CLTCL1, CST3, GXYLT1, HMGA2, SNAI1, VAV2, ZDHHC8) in TAPVC cases compared with controls. 30448225 2018
CUI: C0025500
Disease: Mesothelioma
Mesothelioma 		0.010 Biomarker disease BEFREE SiRNA-induced ZDHHC8 knockdown in 211H and H2052 mesothelioma cells significantly reduced cell survival after X-irradiation. 22017350 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE In 211H tumor-bearing mice, ZDHHC8 siRNA and X-irradiation significantly suppressed tumor growth, whereas ZDHHC8 siRNA alone did not. 22017350 2012