|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study reveals a new role of ZDHHC8-cdc42-palm molecular pathway in postsynaptic structural plasticity and provides new evidence in favor of the dysconnectivity hypothesis for schizophrenia.
|
27365300 |
2017 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
PSYGENET |
ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia.
|
23403413 |
2013 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia.
|
23403413 |
2013 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
PSYGENET |
We investigated the association of the ZDHHC8 gene locus with schizophrenia using meta-analytic techniques, combining all published data up to May 2009 and focusing on 10 independent studies from six published references covering 2,894 cases, 2,932 controls and 1,225 parent-offspring trios.
|
20661937 |
2010 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The results of the present study provide the first evidence that ZDHHC8 on the 22q11 locus might have influence on SPEM function of schizophrenia patients in a Korean population and may provide a new clue for understanding differential effects of candidate genes in schizophrenia.
|
20468065 |
2010 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of the ZDHHC8 gene locus with schizophrenia using meta-analytic techniques, combining all published data up to May 2009 and focusing on 10 independent studies from six published references covering 2,894 cases, 2,932 controls and 1,225 parent-offspring trios.
|
20661937 |
2010 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results of the present study provide the first evidence that ZDHHC8 on the 22q11 locus might have influence on SPEM function of schizophrenia patients in a Korean population and may provide a new clue for understanding differential effects of candidate genes in schizophrenia.
|
20468065 |
2010 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
For further support from within the Han Chinese ethnic group, we selected two single nucleotide polymorphisms (SNP) located at the distal 5'-end (rs1633445; intron 10 of HpaII tiny fragments locus 9C, HTF9C) and the intron 4 (rs175174) of ZDHHC8 gene to test if these were associated with schizophrenia in a study sample of Taiwan.
|
18075473 |
2007 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
PSYGENET |
For further support from within the Han Chinese ethnic group, we selected two single nucleotide polymorphisms (SNP) located at the distal 5'-end (rs1633445; intron 10 of HpaII tiny fragments locus 9C, HTF9C) and the intron 4 (rs175174) of ZDHHC8 gene to test if these were associated with schizophrenia in a study sample of Taiwan.
|
18075473 |
2007 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We selected four putative risk variants, residing within these genes, ProDH 1945, ProDH 2026, COMT ValMet and ZDHHC8 rs175174, and studied these in a large family-based schizophrenia association sample of European origin (488 Bulgarian parent-offspring trios).
|
16860541 |
2006 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
PSYGENET |
We selected four putative risk variants, residing within these genes, ProDH 1945, ProDH 2026, COMT ValMet and ZDHHC8 rs175174, and studied these in a large family-based schizophrenia association sample of European origin (488 Bulgarian parent-offspring trios).
|
16860541 |
2006 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The findings on rs175174 at ZDHHC8 are still far from being conclusive, but evidence for sexual dimorphism is moderate, and our data do not support a significant genetic contribution of rs175174 to the aetiopathogenesis of schizophrenia.
|
16225675 |
2005 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples.
|
15992527 |
2005 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Because our sample size provided quite high power, ZDHHC8 may not play a major role in Japanese schizophrenia.
|
15631889 |
2005 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that the ZDHHC8 gene may not be associated with susceptibility to BPD or schizophrenia, at least in a Japanese population.
|
16150541 |
2005 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
RGD |
The genetic association database.
|
15118671 |
2004 |
|
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Systematic examination of individual genes from the 1.5 Mb critical region has identified so far the PRODH and ZDHHC8 as strong candidate schizophrenia susceptibility genes from this locus.
|
15582150 |
2004 |
|
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results provided compelling supportive evidence for association of the variants within the ZDHHC8 locus with schizophrenia but revealed different risk allele at SNP rs175174.
|
15489219 |
2004 |