ICOS, inducible T cell costimulator, 29851

N. diseases: 193; N. variants: 9
Disease: Systemic Scleroderma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.020 Biomarker disease BEFREE These results identify ICOS<sup>+</sup> T<sub>FH</sub>-like profibrotic cells as key drivers of fibrosis in a GVHD-SSc model and suggest that inhibition of these cells could offer therapeutic benefit for SSc. 29514998 2018
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.020 GeneticVariation disease BEFREE The aim of the present study was to investigate the association of the FOXP3 rs2294020, ICOS rs6726035 and ICOSL rs378299 SNPs with both the susceptibility and the progression to SSc in an Italian case-series of patients. 29030005 2018