|
Granulomatosis with polyangiitis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Cases and controls were matched for AAV (granulomatosis with polyangiitis [GPA], microscopic polyangiitis [MPA] or eosinophilic granulomatosis with polyangiitis [EGPA]), sex and year of enrollment.
|
29180123 |
2018 |
|
Granulomatosis with polyangiitis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Granulomatosis with polyangiitis (GPA, formerly Wegener's granulomatosis) is a multisystem vasculitis of small- to medium-sized blood vessels.
|
29716529 |
2018 |
|
Granulomatosis with polyangiitis
|
0.090 |
Biomarker
|
disease |
BEFREE |
To evaluate circulating cytokine profiles in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), classified by antineutrophil cytoplasmic antibody (ANCA) specificity (proteinase 3 ANCA [PR3-ANCA] versus myeloperoxidase ANCA [MPO-ANCA]) or by clinical diagnosis (granulomatosis with polyangiitis [GPA] versus microscopic polyangiitis [MPA]).
|
29693324 |
2018 |
|
Granulomatosis with polyangiitis
|
0.090 |
Biomarker
|
disease |
BEFREE |
Overall, saddle nose reconstruction in GPA patients is safe even if an increased rate of revision surgery has to be expected compared with individuals without GPA undergoing septorhinoplasty.
|
28881107 |
2018 |
|
Granulomatosis with polyangiitis
|
0.090 |
Biomarker
|
disease |
BEFREE |
A genome-wide association study and subsequent replication study were conducted in a total cohort of 1,986 cases of AAV (patients with granulomatosis with polyangiitis [Wegener's] [GPA] or microscopic polyangiitis [MPA]) and 4,723 healthy controls.
|
28029757 |
2017 |
|
Granulomatosis with polyangiitis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The central role of autoimmunity has been confirmed by the significant association with HLA polymorphisms; interestingly, the three main AAV subtypes are associated with distinct HLA variants, i.e. granulomatosis with polyangiitis (Wegener's GPA) with HLA-DP1, microscopic polyangiitis with HLA-DQ and eosinophilic GPA (Churg-Strauss) with HLA-DRB4.
|
25523449 |
2015 |
|
Granulomatosis with polyangiitis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Overall, metaanalysis showed a statistically significant association between the A allele and ANCA disease in all subjects (OR 1.44, 95% CI 1.26-1.64, p < 0.00001), and stratification by disease category indicated the A allele was associated with granulomatosis with polyangiitis (Wegener's; GPA; OR 1.72, 95% CI 1.35-2.20, p < 0.0001) and microscopic polyangiitis (MPA; OR 1.53, 95% CI 1.08-2.15, p = 0.02) as compared to controls.
|
25448792 |
2015 |
|
Granulomatosis with polyangiitis
|
0.090 |
Biomarker
|
disease |
BEFREE |
In addition, these studies have also shown that different AAV subtypes such as granulomatosis with polyangiitis (Wegener's, GPA) and microscopic polyangiitis (MPA) are underpinned by distinct genetic risk factors, with GPA being associated with HLA-DP, SERPINA1 (encoding α1-antitrypsin), PRTN3 (encoding proteinase-3, PR3, the main GPA-related autoantigen) and SEMA6A (semaphorin 6A), whereas MPA has been mainly associated with HLA-DQ.
|
24854378 |
2014 |
|
Granulomatosis with polyangiitis
|
0.090 |
Biomarker
|
disease |
BEFREE |
The mean values of GPA (CD235a) fluorescence intensity in the group of K562 cells pretreated by the toxin for 24 h and followed by cytosine arabinoside (Ara-C) treatment for 72 h were about 2-fold stronger than those of K562 cells induced by Ara-C alone.
|
24386436 |
2013 |