|
Psoriasis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Therefore, measurement of serum IL-19 provides clinicians with an objective disease-activity assessment tool for psoriasis and atopic dermatitis patients.
|
30914699 |
2019 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Here we show that a deficiency of the TNF superfamily molecule TWEAK (TNFSF12) in mice results in defective maintenance of AD-specific T helper type 2 (Th2) and psoriasis-specific Th17 cells in the skin, and impaired expression of disease-characteristic chemokines and cytokines, such as CCL17 and TSLP in AD, and CCL20 and IL-19 in psoriasis.
|
28530223 |
2017 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Interleukin (IL)-10 family cytokines IL-10, IL-19, IL-20 and IL-24 have been implicated in autoimmune diseases and we have previously reported that genetic variants in the IL10 gene cluster were associated with psoriasis.
|
28150860 |
2017 |
|
Psoriasis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Interleukin-19 (IL-19), a pro-inflammatory cytokine known to stimulate the production of T helper type 2 (Th2) cytokines, is induced by IL-17A and highly expressed in the lesional skin of psoriasis and atopic dermatitis (AD).
|
28597022 |
2017 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Psoriasis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Resveratrol ameliorates psoriasis, and changes expression of retinoic acid stimulated genes, IL-17 signalling pathways, IL-17A and IL-19 mRNA levels in a beneficial manner, which suggests resveratrol, might have a role in the treatment of psoriasis and should be explored further in a human setting.
|
25965695 |
2015 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Interleukin 19 (IL-19), IL-20 and IL-24 signal through type I and type II IL-20 receptors and are associated with inflammatory skin diseases such as psoriasis and atopic dermatitis.
|
23793061 |
2013 |
|
Psoriasis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
It is known that expression of IL-19 is increased in the epidermis of patients with psoriasis, which is a Th1 dominant disease.
|
22103848 |
2011 |
|
Psoriasis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
IL-17A and IL-19 are highly expressed in chronic inflammatory diseases, such as psoriasis and asthma.
|
18539194 |
2008 |
|
Psoriasis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
IL-23 induced IL-19 and IL-24 expression in mouse skin, and both genes were also elevated in human psoriasis.
|
17074928 |
2006 |
|
Psoriasis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
During treatment with calcipotriol or CsA, IL-19 and IL-20 mRNA levels decrease in accordance with the clinical improvement of psoriasis.
|
16225599 |
2005 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Nevertheless, family-based studies are required to confirm the impact of IL-19, IL-20 and IL-24 genes in the genetic predisposition for psoriasis.
|
15889129 |
2005 |
|
Psoriasis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Patients with psoriasis had a lower level of IL-19 in serum than healthy volunteers.
|
16120148 |
2005 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Although association analysis of the IL-19 gene indicated that minor alleles of the IL-19 gene SNPs (rs2243188, rs2243169 and rs2243158) revealed protective effect to psoriasis and haplotype analysis of the IL-19 gene proved significant protective effect of the TGATA haplotype in case of late-onset disease, combined haplotype analysis of the IL-19 and -20 genes demonstrated that protective effect of the IL-19 gene is secondary to the susceptibility effect of the IL-20 gene.
|
15496954 |
2004 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
It remains to be clarified whether IL-19 and IL-20 are implicated in the pathogenesis of psoriasis.
|
14675174 |
2003 |