|
Polycystic Ovary Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.
|
21411543 |
2011 |
|
Sclerocystic Ovaries
|
0.300 |
Biomarker
|
disease |
CTD_human |
Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.
|
21411543 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The protein interacting with carboxyl terminus-1 (PICT-1) gene has been implicated as a tumor suppressor gene, and its alterations have been reported in several cancers.
|
29617699 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor tissue katanin P60 expression correlates with lymph node metastasis and worse prognosis in patients with breast cancer: A cohort study.
|
29103029 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical staining of tumor samples revealed that lower levels of PICT-1 were observed in samples from CIN III and cervical cancer tissues, compared to normal cervical epithelium and CIN I, II tissues (P < 0.05).
|
27996172 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nucleolar protein PICT-1/GLTSCR2 (GLTSCR2) has both tumor suppressive and oncogenic activities, depending on the types of cancer tissue and its expression level.
|
26724143 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PICT-1 was originally identified as a tumor suppressor.
|
27729611 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
GLTSCR2 was originally identified as a candidate tumor suppressor in several types of cancers.
|
25118835 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Reduction of GLTSCR2 was significantly correlated with increased histological grade (p<0.005), increased tumor size (p<0.001), axillary lymph node involvement (p<0.001) and decreased disease free survival (p<0.025).
|
24054033 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We analyzed cutaneous SCC (n=42), basal cell carcinomas (BCC; n=26), and normal skin tissue samples (n=36) and compared GLTSCR2 expression between tumor and normal tissues, using immunohistochemistry.
|
23942755 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our results indicate that GLTSCR2 functions as a tumor suppressor in prostatic adenocarcinomas.
|
23920125 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In human cancer, individuals whose tumors express less PICT1 have better prognoses.
|
21804542 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although the detailed mechanisms are not fully understood, several lines of evidence have previously implicated PICT-1 as a candidate tumour suppressor, including its phosphatase and tensin homolog deleted on chromosome 10 (PTEN)-dependent growth-suppression and cell-killing activities.
|
21167305 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This is the first study analyzing the expression of GLTSCR2, a putative tumor suppressor, in SK and normal skin.
|
20185249 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Finally, our immunohistochemical study demonstrates that GLTSCR2 is sequentially down-regulated according to the histological malignant progression of the astrocytic glial tumour.
|
18729076 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, these results suggest that PICT-1 plays a role in PIP(3) signals through controlling PTEN protein stability and the impairment in the PICT-1-PTEN regulatory unit may become a causative factor in human tumor(s).
|
16971513 |
2006 |
|
Carcinogenesis
|
0.050 |
GeneticVariation
|
phenotype |
BEFREE |
This study investigated the association of PICT-1 alterations with endometrial carcinogenesis.
|
29617699 |
2018 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
For example, PICT1 binds to and anchors RPL11 in nucleoli, down-regulating p53 and promoting tumorigenesis.
|
28722511 |
2017 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
GLTSCR2 (also known as PICT-1) is a nucleolar protein involved in both tumor suppression and oncogenesis in concert with p53, NPM, and/or MYC.
|
27323397 |
2017 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
The reduction of PICT-1 may therefore be an early event in uterine cervical tumorigenesis.
|
27996172 |
2017 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
GLTSCR2 may play an important role in carcinogenesis of cervical cancer.
|
25118835 |
2015 |
|
Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We found that repeated hypoxia downregulates p53-upstream regulator, GLTSCR2, which resulted in increased death resistance and invasive potential of glioblastoma cells.
|
22850112 |
2012 |
|
Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus.
|
21167305 |
2011 |
|
Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In a recent study, we demonstrated that GLTSCR2 often exhibits genetic alterations and down-regulation in glioblastoma specimens.
|
20185249 |
2010 |
|
Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
In addition, direct sequencing analysis and fluorescence in situ hybridization clearly demonstrates the presence of genetic alterations, such as a nonsense mutation and deletion, in the GLTSCR2 gene in glioblastomas.
|
18729076 |
2008 |