TBX21, T-box transcription factor 21, 30009

N. diseases: 124; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma 		0.700 GeneticVariation disease GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738 2019
CUI: C0004096
Disease: Asthma
Asthma 		0.700 GeneticVariation disease BEFREE Furthermore, haplotypes TG (OR=2.83; P=0.001) and TA (OR=2.54; P=0.001) of TBX21 were associated with an increased risk of asthma. 25056814 2014
CUI: C0004096
Disease: Asthma
Asthma 		0.700 GeneticVariation disease BEFREE Mice with a targeted deletion of the T-bet gene and severe combined immunodeficient mice receiving CD4+ cells from T-bet knockout mice spontaneously demonstrated multiple physiological and inflammatory features characteristic of asthma. 11786643 2002
CUI: C0004096
Disease: Asthma
Asthma 		0.700 GeneticVariation disease BEFREE Eighty-two children (56 boys/26 girls, mean age 9.6 ± 3.2 years) with moderate-severe asthma exacerbation were genotyped for eight single-nucleotide polymorphisms that were a priori associated with ICS response in chronic asthma treatment: glucocorticosteroid receptor (NR3C1) rs41423247; corticotrophin-releasing hormone receptor1 (CRHR1) rs242939, rs242941, and rs1876828; T-box 21 (TBX21) rs2240017; glucocorticoid-induced transcript 1 (GLCCl1); and T gene rs3099266 and rs2305089. 27003716 2016
CUI: C0004096
Disease: Asthma
Asthma 		0.700 GeneticVariation disease BEFREE Using statistical analyses for association of TBX21 polymorphisms with these three asthma phenotypes, no significant signals were detected. 12938094 2003
CUI: C0004096
Disease: Asthma
Asthma 		0.700 GeneticVariation disease BEFREE Among the genes identified, variants in T-box 21 ( TBX21) and Fc fragment of IgE receptor II ( FCER2) contribute indirectly to the variability in the response to ICS by altering the inflammatory mechanisms in asthma, while other genes such as corticotropin releasing hormone receptor 1 ( CRHR1), nuclear receptor subfamily 3 group C member 1 ( NR3C1), stress induced phosphoprotein 1 ( STIP1), dual specificity phosphatase 1 (DUSP1), glucocorticoid induced 1 (GLCCI1), histone deacetylase 1 (HDAC), ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3), and vascular endothelial growth factors (VEGF) directly affect this variability through the anti-inflammatory mechanisms of ICS. 29251255 2017
CUI: C0004096
Disease: Asthma
Asthma 		0.700 GeneticVariation disease LHGDN T-bet polymorphisms are associated with asthma and airway hyperresponsiveness. 16179640 2006
CUI: C0004096
Disease: Asthma
Asthma 		0.700 GeneticVariation disease BEFREE Of the four genetic polymorphisms examined, NK2R G231E G>A and TBX21 H33Q C>G were significantly associated with asthma control status (P = 0.041 and P = 0.006). 20175803 2009
CUI: C0004096
Disease: Asthma
Asthma 		0.700 GeneticVariation disease LHGDN TBX21 may thus be an important determinant pharmacogenetic response to the therapy of asthma with inhaled corticosteroids. 15604153 2004
CUI: C0004096
Disease: Asthma
Asthma 		0.700 GeneticVariation disease LHGDN An association between a specific TBX21 haplotype and allergic asthma in children is demonstrated for the first time and might explain previously detected associations between SNPs within TBX21 and asthma and bronchial hyperresponsiveness. 17949803 2008
CUI: C0004096
Disease: Asthma
Asthma 		0.700 GeneticVariation disease BEFREE Polymorphisms in TBX21, a gene important for the biological action of corticosteroids, could be associated with treatment response in asthmatics. 24107858 2013
CUI: C0004096
Disease: Asthma
Asthma 		0.700 GeneticVariation disease BEFREE Furthermore, the impact of combinations of TBX21 and HLX1 polymorphisms on the development of asthma was assessed by using a risk score model. 19362357 2009
CUI: C0004096
Disease: Asthma
Asthma 		0.700 GeneticVariation disease BEFREE This study investigated the influence of TBX21 and HLX1 single nucleotide polymorphisms (SNPs), which have previously been shown to be associated with asthma, on T(H)1/T(H)2 lineage cytokines at birth. 22303482 2012
CUI: C0004096
Disease: Asthma
Asthma 		0.700 GeneticVariation disease LHGDN In order to examine whether polymorphisms in the candidate gene, TBX21, located on chromosome 17q21.32, are related to the risk of human asthma phenotypes, we have searched for genetic variations in the human TBX21 gene and identified 24 single nucleotide polymorphisms (SNPs), including five novel SNPs, by direct sequencing in Japanese subjects. 15806396 2005
CUI: C1319853
Disease: Asthma, Aspirin-Induced
Asthma, Aspirin-Induced 		0.410 GeneticVariation disease BEFREE Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. 15806396 2005
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.120 GeneticVariation disease BEFREE TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants. 19362357 2009
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.120 GeneticVariation disease GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433 2019
CUI: C0014772
Disease: Red Blood Cell Count measurement
Red Blood Cell Count measurement 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0200638
Disease: Eosinophil count procedure
Eosinophil count procedure 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0524587
Disease: Mean Corpuscular Volume (result)
Mean Corpuscular Volume (result) 		0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C1261502
Disease: Finding of Mean Corpuscular Hemoglobin
Finding of Mean Corpuscular Hemoglobin 		0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C1261502
Disease: Finding of Mean Corpuscular Hemoglobin
Finding of Mean Corpuscular Hemoglobin 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.060 GeneticVariation disease BEFREE The aim of this study was to evaluate whether T-bet gene (TBX21) polymorphisms or its haplotypes are associated with SLE in a Chinese population. 20429676 2010
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.060 GeneticVariation disease BEFREE Previously, two single nucleotide polymorphisms (SNPs) in the TBX21 promoter, T-1993C and T-1514C, have been shown by statistic studies to associate with systemic lupus erythematosus (SLE). 22258560 2012
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.060 GeneticVariation disease BEFREE Recent studies have shown that genetic variants in TBX21 and IFNG are connected with risk of systemic lupus erythematosus (SLE). 26916970 2016