|
Asthma
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Among the genes identified, variants in T-box 21 ( TBX21) and Fc fragment of IgE receptor II ( FCER2) contribute indirectly to the variability in the response to ICS by altering the inflammatory mechanisms in asthma, while other genes such as corticotropin releasing hormone receptor 1 ( CRHR1), nuclear receptor subfamily 3 group C member 1 ( NR3C1), stress induced phosphoprotein 1 ( STIP1), dual specificity phosphatase 1 (DUSP1), glucocorticoid induced 1 (GLCCI1), histone deacetylase 1 (HDAC), ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3), and vascular endothelial growth factors (VEGF) directly affect this variability through the anti-inflammatory mechanisms of ICS.
|
29251255 |
2017 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Eighty-two children (56 boys/26 girls, mean age 9.6 ± 3.2 years) with moderate-severe asthma exacerbation were genotyped for eight single-nucleotide polymorphisms that were a priori associated with ICS response in chronic asthma treatment: glucocorticosteroid receptor (NR3C1) rs41423247; corticotrophin-releasing hormone receptor1 (CRHR1) rs242939, rs242941, and rs1876828; T-box 21 (TBX21) rs2240017; glucocorticoid-induced transcript 1 (GLCCl1); and T gene rs3099266 and rs2305089.
|
27003716 |
2016 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, haplotypes TG (OR=2.83; P=0.001) and TA (OR=2.54; P=0.001) of TBX21 were associated with an increased risk of asthma.
|
25056814 |
2014 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in TBX21, a gene important for the biological action of corticosteroids, could be associated with treatment response in asthmatics.
|
24107858 |
2013 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study investigated the influence of TBX21 and HLX1 single nucleotide polymorphisms (SNPs), which have previously been shown to be associated with asthma, on T(H)1/T(H)2 lineage cytokines at birth.
|
22303482 |
2012 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Of the four genetic polymorphisms examined, NK2R G231E G>A and TBX21 H33Q C>G were significantly associated with asthma control status (P = 0.041 and P = 0.006).
|
20175803 |
2009 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the impact of combinations of TBX21 and HLX1 polymorphisms on the development of asthma was assessed by using a risk score model.
|
19362357 |
2009 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
An association between a specific TBX21 haplotype and allergic asthma in children is demonstrated for the first time and might explain previously detected associations between SNPs within TBX21 and asthma and bronchial hyperresponsiveness.
|
17949803 |
2008 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
An association between a specific TBX21 haplotype and allergic asthma in children is demonstrated for the first time and might explain previously detected associations between SNPs within TBX21 and asthma and bronchial hyperresponsiveness.
|
17949803 |
2008 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, (1) p38MAPK-pathway rather than ERK-pathway may play a more basic role in the regulation of the increased T-bet expression in asthma, and (2) ERK- and p38MAPK-activation modulate IFNgamma expression independently of T-bet and this regulatory role of ERK-1/-2 on IFNgamma release is impaired in asthma.
|
17127048 |
2007 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
AM could increase the expression of T-bet mRNA and Thl cytokines such as IFN-Y, and might reverse the Th2 predominant status in asthma patients.
|
17361521 |
2006 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
T-bet polymorphisms are associated with asthma and airway hyperresponsiveness.
|
16179640 |
2006 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
CTD_human |
In order to examine whether polymorphisms in the candidate gene, TBX21, located on chromosome 17q21.32, are related to the risk of human asthma phenotypes, we have searched for genetic variations in the human TBX21 gene and identified 24 single nucleotide polymorphisms (SNPs), including five novel SNPs, by direct sequencing in Japanese subjects.
|
15806396 |
2005 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Mice lacking the T-bet gene (tbx21) demonstrate multiple physiological and inflammatory features reminiscent of human asthma.
|
15806396 |
2005 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
In order to examine whether polymorphisms in the candidate gene, TBX21, located on chromosome 17q21.32, are related to the risk of human asthma phenotypes, we have searched for genetic variations in the human TBX21 gene and identified 24 single nucleotide polymorphisms (SNPs), including five novel SNPs, by direct sequencing in Japanese subjects.
|
15806396 |
2005 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Within the Finnish asthmatic founder population, there was no association between T-bet SNPs and high serum IgE level or asthma.
|
15248849 |
2004 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
TBX21 may thus be an important determinant pharmacogenetic response to the therapy of asthma with inhaled corticosteroids.
|
15604153 |
2004 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
TBX21 may thus be an important determinant pharmacogenetic response to the therapy of asthma with inhaled corticosteroids.
|
15604153 |
2004 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Using statistical analyses for association of TBX21 polymorphisms with these three asthma phenotypes, no significant signals were detected.
|
12938094 |
2003 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
MGD |
Mice with a targeted deletion of the T-bet gene and severe combined immunodeficient mice receiving CD4+ cells from T-bet knockout mice spontaneously demonstrated multiple physiological and inflammatory features characteristic of asthma.
|
11786643 |
2002 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
MGD |
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.
|
11786644 |
2002 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Mice with a targeted deletion of the T-bet gene and severe combined immunodeficient mice receiving CD4+ cells from T-bet knockout mice spontaneously demonstrated multiple physiological and inflammatory features characteristic of asthma.
|
11786643 |
2002 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Asthma, Aspirin-Induced
|
0.410 |
Biomarker
|
disease |
CTD_human |
Several single nucleotide polymorphisms (SNPs) in the promoters of EP2, TBX21, COX-2, Fc epsilon RIbeta, and TBXA2R were associated with AIA, while an Fc epsilon RIalpha promoter polymorphism was associated with AIU.
|
16502481 |
2006 |