TBX21, T-box transcription factor 21, 30009

N. diseases: 124; N. variants: 12
Disease: Dermatitis, Atopic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.030 Biomarker disease BEFREE Associations between umbilical cord methylation of CpG loci within IL-4R with atopic eczema at 12 months (median ratio 1.02, P = .028), and TBET with atopy (median ratio 0.98, P = .017) at 6-7 years of age were also observed. 28756630 2017
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.030 GeneticVariation disease BEFREE TBX21 SNP rs11079788 carriers developed less symptoms of atopic dermatitis at 3 years of age (p = 0.03). 22303482 2012
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.030 AlteredExpression disease BEFREE Semi-quantitative RT-PCR revealed that in peripheral blood mononuclear cells without any stimulation the levels of mRNA for GATA-3 and SOCS-3 were elevated, the levels of mRNA for Txk were depressed and the levels of mRNA for T-bet and SOCS-5 were comparable in patients with atopic dermatitis as compared with healthy controls. 15008986 2004