GZMB, granzyme B, 3002

N. diseases: 290; N. variants: 5
Disease: Colorectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 Biomarker disease BEFREE Tumour-infiltrating lymphocytes (TILs) and Granzyme B play crucial roles in immune reactions against colorectal carcinoma (CRCa). 29970545 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 Biomarker disease BEFREE Including CTL and GZMB scores simultaneously in the model significantly improved the predictive performance of the models for all-cause and colorectal cancer-related death.<b>Conclusions:</b> Higher tumor infiltration with CTL and GZMB cells is associated with improved all-cause and cancer-specific survival of colorectal cancer patients.<b>Impact:</b> Both the number of CTLs and GZMB appear to be useful prognostic factors in colorectal cancer, irrespective of stage. 27979806 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 AlteredExpression disease BEFREE In addition, we investigated the effect of DHA on CRC cell-associated GrB expression, EMT and invasion. 26830472 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 GeneticVariation disease BEFREE In this study, we examined possible association between GZMB gene polymorphisms and susceptibility to colorectal cancer (CRC). 25313744 2015
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.050 AlteredExpression disease BEFREE Low expression of Granzyme B was associated with early signs of metastasis in CRC. 21884199 2011