GZMB, granzyme B, 3002

N. diseases: 290; N. variants: 5
Disease: Hepatitis C ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.040 Biomarker disease BEFREE The cytolysis of HCV-infected hepatocytes is mediated by perforin and granzyme B secreted by cytotoxic T lymphocyte (CTL) and natural killer (NK) cells, whereas noncytolytic HCV clearance is mediated by interferon gamma (IFN-γ) secreted by CTL and NK cells. 31027278 2019
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.040 Biomarker disease BEFREE Compared to controls, virally infected pts displayed significantly lower circulating Vα7.2+CD161++CD8+ MAIT cells (<i>p</i> = 0.001), yet expressed higher perforin (<i>p</i> = 0.004) and granzyme B (<i>p</i> = 0.002) on CD8+ MAIT cells.Upon <i>E. coli</i> stimulation, the residual MAIT cells are less functional particularly those from HIV+/HCV+ patients. 31555223 2019
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.040 AlteredExpression disease BEFREE This is the first study demonstrating the activation of GrB+CD4+ T cells against antigen(s) derived from HCV. 19616202 2009
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.040 Biomarker disease BEFREE We evaluated PDC-dependent NK cell killing and gamma interferon (IFN-gamma) and granzyme B production, using peripheral blood mononuclear cell (PBMC)-based and purified cell assays of samples from HCV- and HIV-infected subjects. 19692459 2009