HBG1, hemoglobin subunit gamma 1, 3047

N. diseases: 65; N. variants: 8
Disease: Sickle Cell Trait ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0037054
Disease: Sickle Cell Trait
Sickle Cell Trait 		0.020 Biomarker disease BEFREE Our findings offer the prospect of using this approach to reduce the proportion of intracellular hemoglobin S. Gene therapy strategies which combine gamma-globin induction along with beta-globin inhibition using antisense vectors may yield more favorable anti-sickling effects longterm. 15040426 2004
CUI: C0037054
Disease: Sickle Cell Trait
Sickle Cell Trait 		0.020 Biomarker disease BEFREE Human gamma-globin and delta-globin chains have been previously identified as strong inhibitors of the polymerization of hemoglobin S, in contrast to the beta-globin chain, which exerts only a moderate antisickling effect. 7708766 1995