HBG1, hemoglobin subunit gamma 1, 3047

N. diseases: 65; N. variants: 8
Disease: Sickle Cell-SS Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4321477
Disease: Sickle Cell-SS Disease
Sickle Cell-SS Disease 		0.010 Biomarker disease BEFREE Here we show that ACY-957, a selective chemical inhibitor of HDAC1 and 2 (HDAC1/2), elicits a dose and time dependent induction of γ-globin mRNA (HBG) and HbF in cultured primary cells derived from healthy individuals and sickle cell patients. 27073918 2016