HCRTR1, hypocretin receptor 1, 3061

N. diseases: 71; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.320 GeneticVariation group BEFREE An HCRTR1 gene variant (rs2271933 G > A) leading to amino acid substitution (Ile408Val) has been associated with migraine and mood disorders. 30742846 2019
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.320 GeneticVariation group BEFREE Our study suggests that the HCRTR1 gene or a linked locus may modulate the risk for Major Mood Disorders and supports recent studies suggesting an involvement of hypocretin neurotransmitter system in affective disorders. 21071097 2011
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.320 Biomarker group PSYGENET Our study suggests that the HCRTR1 gene or a linked locus may modulate the risk for Major Mood Disorders and supports recent studies suggesting an involvement of hypocretin neurotransmitter system in affective disorders. 21071097 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 GeneticVariation disease BEFREE [2005 Biol Psychiatry 58 401-407] reported an association between the 408Val allele of the orexin 1 receptor (HCRTR1) gene and polydipsia-hyponatremia in a sample of Japanese patients with SCZ. 17999203 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 GeneticVariation disease LHGDN [2005 Biol Psychiatry 58 401-407] reported an association between the 408Val allele of the orexin 1 receptor (HCRTR1) gene and polydipsia-hyponatremia in a sample of Japanese patients with SCZ. 17999203 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease PSYGENET [2005 Biol Psychiatry 58 401-407] reported an association between the 408Val allele of the orexin 1 receptor (HCRTR1) gene and polydipsia-hyponatremia in a sample of Japanese patients with SCZ. 17999203 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 GeneticVariation disease BEFREE Screening of the orexin signaling system detected a 408 isoleucine to valine mutation in HCRTR1 that showed significant genotypic association with polydipsic-hyponatremic schizophrenia (p = .012). 15978554 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease PSYGENET Screening of the orexin signaling system detected a 408 isoleucine to valine mutation in HCRTR1 that showed significant genotypic association with polydipsic-hyponatremic schizophrenia (p = .012). 15978554 2005
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.310 Biomarker disease BEFREE Across numerous experiments, we and others have identified a critical influence of hypocretin receptor 1 in mediating the behavioral and physiological effects of cocaine which positions this receptor as a potential target for the treatment of cocaine addiction. 30071195 2020
CUI: C0038587
Disease: Substance Withdrawal Syndrome
Substance Withdrawal Syndrome 		0.310 Biomarker disease BEFREE Antagonism of orexin type-1 receptors (OX1Rs) attenuates naloxone-precipitated morphine withdrawal syndrome in rat dorsal hippocampus. 28583577 2017
CUI: C0038587
Disease: Substance Withdrawal Syndrome
Substance Withdrawal Syndrome 		0.310 Biomarker disease CTD_human Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats. 20667500 2010
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.310 Biomarker disease CTD_human Orexin/hypocretin is necessary for context-driven cocaine-seeking. 19591850 2010
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.310 Biomarker disease CTD_human Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers. 19741128 2009
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.310 Biomarker disease CTD_human Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. 16357203 2005
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.300 Biomarker disease PSYGENET Yohimbine depresses excitatory transmission in BNST and impairs extinction of cocaine place preference through orexin-dependent, norepinephrine-independent processes. 22617356 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.300 Biomarker disease PSYGENET Yohimbine depresses excitatory transmission in BNST and impairs extinction of cocaine place preference through orexin-dependent, norepinephrine-independent processes. 22617356 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.300 Biomarker disease PSYGENET Hcrtr1 and 2 signaling differentially regulates depression-like behaviors. 21377495 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.300 Biomarker disease PSYGENET Hcrtr1 and 2 signaling differentially regulates depression-like behaviors. 21377495 2011
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker disease CTD_human Orexin/hypocretin is necessary for context-driven cocaine-seeking. 19591850 2010
CUI: C0086189
Disease: Drug Withdrawal Symptoms
Drug Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats. 20667500 2010
CUI: C0087169
Disease: Withdrawal Symptoms
Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats. 20667500 2010
CUI: C0236736
Disease: Cocaine-Related Disorders
Cocaine-Related Disorders 		0.300 Biomarker group CTD_human Orexin/hypocretin is necessary for context-driven cocaine-seeking. 19591850 2010
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker disease CTD_human Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers. 19741128 2009
CUI: C0236736
Disease: Cocaine-Related Disorders
Cocaine-Related Disorders 		0.300 Biomarker group CTD_human Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers. 19741128 2009
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker disease CTD_human Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. 16357203 2005