HCRTR1, hypocretin receptor 1, 3061

N. diseases: 71; N. variants: 6
Disease: Anxiety ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003467
Disease: Anxiety
Anxiety 		0.040 GeneticVariation disease BEFREE Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes. 30718541 2019
CUI: C0003467
Disease: Anxiety
Anxiety 		0.040 Biomarker disease BEFREE In conclusion, the data suggest that manipulation of OX1R and CB1 receptors in the vlPAG alters capsaicin-evoked anxiety like behaviors and c-fos induction in rats. 30587409 2019
CUI: C0003467
Disease: Anxiety
Anxiety 		0.040 Biomarker disease BEFREE These results together suggest that orexinergic modulation of DRN 5-HT neurons via OX1Rs may be one pathway through which orexin regulates mood and anxiety, as well as perhaps other neurobiological processes. 31445011 2019
CUI: C0003467
Disease: Anxiety
Anxiety 		0.040 Biomarker disease BEFREE SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats. 27739093 2017