HCRTR1, hypocretin receptor 1, 3061

N. diseases: 71; N. variants: 6
Disease: Malignant tumor of colon ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.030 AlteredExpression disease BEFREE Based on our recent studies showing that OX1R is aberrantly expressed in colon cancer, we wondered whether orexin-A could play a role in UC. 30251681 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.030 Biomarker disease BEFREE Dual-agonist occupancy of orexin receptor 1 and cholecystokinin A receptor heterodimers decreases G-protein-dependent signaling and migration in the human colon cancer cell line HT-29. 28288880 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.030 AlteredExpression disease BEFREE Next, we showed that nine human colon cancer cell lines established from primary tumors or metastases expressed OX1R mRNA and underwent important apoptosis on orexin-A challenge. 21415167 2011