HCRTR1, hypocretin receptor 1, 3061

N. diseases: 71; N. variants: 6
Disease: Hypertensive disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.020 Biomarker group BEFREE Furthermore, upregulation of the orexin receptor 1 increases firing of hypothalamic paraventricular nucleus neurons, augments SNA, and contributes to hypertension in the obese Zucker rat, an animal model of obesity-related hypertension. 28349223 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.020 Biomarker group BEFREE These results suggest that elevated PVN OX1R activation may contribute to SSHTN by enhancing AVP signaling.<b>NEW & NOTEWORTHY</b> To our best knowledge, this study is the first to investigate the involvement of the orexin system in salt-sensitive hypertension. 28667055 2017