Narcolepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models.
|
10615891 |
2000 |
Narcolepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The positional cloning of the hypocretin receptor 2, the gene for autosomal recessive canine narcolepsy, has led to the development of a physical map spanning a large portion of canine chromosome 12 (CFA12), in a region corresponding to human chromosome 6p12-q13.
|
11350122 |
2001 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have determined that canine narcolepsy is caused by disruption of the hypocretin (orexin) receptor 2 gene (Hcrtr2).
|
10458611 |
1999 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
MGD |
To identify the neuronal circuits underlying narcolepsy, we produced a mouse model in which a loxP-flanked gene cassette disrupts production of the orexin receptor type 2 (OX2R; also known as HCRTR2), but normal OX2R expression can be restored by Cre recombinase.
|
21368172 |
2011 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Expression of the hypocretin/orexin receptor HCRTR2, which has been implicated in narcolepsy, correlated with sleep disturbance.
|
16376318 |
2006 |
Narcolepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Hcrtr2 mutations underlie the etiology of canine narcolepsy, deficiencies in orexin-producing neurons are observed in the human disorder, and ablation of mouse orexin neurons or the Hcrt gene results in a narcolepsy-cataplexy phenotype.
|
22759794 |
2012 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
MGD |
Hcrtr1 and 2 signaling differentially regulates depression-like behaviors.
|
21377495 |
2011 |
Narcolepsy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To determine whether hypocretin receptor gene (hcrtR1 and hcrtR2) expression is affected after long-term hypocretin ligand loss in humans and animal models of narcolepsy.
|
18714784 |
2008 |
Narcolepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The orexin-2/hypocretin-2 (OX2R) receptor gene is mutated in canine narcolepsy and disruption of the prepro-orexin/hypocretin ligand gene results in both an animal model of narcolepsy and sporadic cases of the human disease.
|
15274044 |
2004 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
MGD |
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes.
|
12797957 |
2003 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
HCRTR2-Abs are not common in narcolepsy unrelated to vaccination.
|
28364500 |
2017 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Among hypocretin replacement strategies, developing non-peptide hypocretin receptor agonists is currently the most encouraging since systemic administration of a newly synthesized, selective hypocretin receptor 2 agonist (YNT-185) has been shown to ameliorate symptoms of narcolepsy in murine models.
|
29623725 |
2018 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases.
|
29220370 |
2017 |
Narcolepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, 11 sporadic cases of canine narcolepsy and two additional multiplex families were investigated for possible Hcrt and Hcrtr2 mutations.
|
11282968 |
2001 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
CTD_human |
By using microarray technology we have screened the expression of 29760 genes in the brains of Doberman dogs with a heritable form of narcolepsy (homozygous for the canarc-1 [HCRTR-2-2] mutation), and their unaffected heterozygous siblings.
|
17521418 |
2007 |
Narcolepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study of American and Icelandic patients with narcolepsy, the authors found no significant association between narcolepsy and single-nucleotide polymorphisms in the genes for hypocretin or its two known receptors, hypocretin receptor-1 and hypocretin receptor-2.
|
11723285 |
2001 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
We detected autoantibodies against hypocretin in 3 patients, hcrtrl in 1 patient, and hcrtr2 in 5 patients with narcolepsy.
|
16774153 |
2006 |
Narcolepsy-Cataplexy Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain.
|
17521418 |
2007 |
Hyperglycemia
|
0.200 |
Therapeutic
|
disease |
RGD |
Expressions of the prepro-orexin and orexin type 2 receptor genes in obese rat.
|
12217430 |
2002 |
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three new polymorphisms of the HCRTR2 gene resulted significantly associated with CH.
|
18399985 |
2008 |
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene.
|
16554494 |
2006 |
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Associations between cluster headache and polymorphism rs2653349 of the HCRTR2 gene have been demonstrated.
|
29959630 |
2018 |
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache.
|
15477554 |
2004 |
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The HCRTR2 1246G > A and the ADH4 925A > G polymorphisms have been associated with CH.
|
20425202 |
2010 |
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 575 cluster headache patients from our LUCA study and 874 controls were genotyped for HCRTR2 SNP rs2653349 but no significant association with cluster headache was found (odds ratio 0.91 (95% confidence intervals 0.75-1.10), p = 0.319).
|
25398231 |
2015 |