|
Addictive Behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In this regard, studies on both orexin-1 receptors (OX1Rs) and orexin-2 receptors (OX2Rs) have shown some positive results, suggesting that single orexin receptor antagonists (SORAs) and dual orexin receptor antagonists (DORAs) may hold promising efficacy in the treatment of addiction compared to the currently used methods.
|
30476469 |
2020 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
LHGDN |
All adenomas expressed OX1-R and OX2-R mRNAs, and real-time PCR showed that the expression of both receptors was up-regulated in adenomas, compared with normal adrenal cortex.
|
15797953 |
2005 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
All adenomas expressed OX1-R and OX2-R mRNAs, and real-time PCR showed that the expression of both receptors was up-regulated in adenomas, compared with normal adrenal cortex.
|
15797953 |
2005 |
|
Alzheimer's Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The rs9370399 (OX2R) has also shown an association between A allele (p=0.03, OR= 1.4) and AD.
|
27335043 |
2016 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
The aim of our study was to investigate whether genetic variants in the hypocretin (HCRT) and in the hypocretin receptors 1 and 2 (HCRTR1, HCRTR2) genes could modify the occurrence and the clinical features of AD and to examine if these possible variants influence the role of the protein in sleep regulation.
|
24969517 |
2014 |
|
Anorexia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results of the present study suggest that the C‑terminus of OX2R is important for its role in various physiological and pathological processes, and may therefore be associated with such disorders as depression and anorexia.
|
28487995 |
2017 |
|
Blood urea nitrogen measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
|
31152163 |
2019 |
|
Carcinoma, Endometrioid
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression and epigenetic regulation of type 2 orexin receptor (OX2R) was investigated in the human endometrium as well as in endometrial endometrioid carcinoma (EEC).
|
23482607 |
2013 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus, in addition to the known central effects of orexins/OX2R, the work of Patel and colleagues (<i>Clinical Science</i> (2018) <b>132</b>, 2547-2564) reports a direct action of OR-B on the heart rate pinpointing to OX2R as a potential therapeutic target for prevention and treatment of cardiovascular disease.
|
30948623 |
2019 |
|
Circadian Rhythms
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits.
|
27992416 |
2017 |
|
Circadian Rhythms
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person.
|
26835600 |
2016 |
|
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three new polymorphisms of the HCRTR2 gene resulted significantly associated with CH.
|
18399985 |
2008 |
|
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene.
|
16554494 |
2006 |
|
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Associations between cluster headache and polymorphism rs2653349 of the HCRTR2 gene have been demonstrated.
|
29959630 |
2018 |
|
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache.
|
15477554 |
2004 |
|
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The HCRTR2 1246G > A and the ADH4 925A > G polymorphisms have been associated with CH.
|
20425202 |
2010 |
|
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 575 cluster headache patients from our LUCA study and 874 controls were genotyped for HCRTR2 SNP rs2653349 but no significant association with cluster headache was found (odds ratio 0.91 (95% confidence intervals 0.75-1.10), p = 0.319).
|
25398231 |
2015 |
|
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache.
|
15477554 |
2004 |
|
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two other HCRTR2 gene variants, rs2653342 and rs2653349, have been reported to be linked to cluster headache in an Italian study.
|
30652302 |
2019 |
|
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study does not support a major contribution of the HCRTR2 G1246A polymorphism to the pathogenesis of migraine in contrast to its effects in cluster headache.
|
17883525 |
2007 |
|
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Our data confirm that the G1246A polymorphism of the HCRTR2 gene may modulate the genetic risk for CH.
|
17563843 |
2007 |
|
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results do not support a role of the HCRTR2 G1246A polymorphism in drug responses in CH.
|
17376114 |
2007 |
|
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HCRTR2 gene rs2653349 and ADH4 gene rs1800759 polymorphisms have been associated with cluster headache susceptibility.
|
31768945 |
2020 |
|
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data confirm that the G1246A polymorphism of the HCRTR2 gene may modulate the genetic risk for CH.
|
17563843 |
2007 |
|
Cluster Headache
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A genome-wide scan and HCRTR2 candidate gene analysis in a European cluster headache cohort.
|
16801656 |
2006 |