HCRTR2, hypocretin receptor 2, 3062

N. diseases: 37; N. variants: 11
Disease: Cluster Headache ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009088
Disease: Cluster Headache
Cluster Headache 		0.100 GeneticVariation disease BEFREE HCRTR2 gene rs2653349 and ADH4 gene rs1800759 polymorphisms have been associated with cluster headache susceptibility. 31768945 2020
CUI: C0009088
Disease: Cluster Headache
Cluster Headache 		0.100 GeneticVariation disease BEFREE Two other HCRTR2 gene variants, rs2653342 and rs2653349, have been reported to be linked to cluster headache in an Italian study. 30652302 2019
CUI: C0009088
Disease: Cluster Headache
Cluster Headache 		0.100 GeneticVariation disease BEFREE Associations between cluster headache and polymorphism rs2653349 of the HCRTR2 gene have been demonstrated. 29959630 2018
CUI: C0009088
Disease: Cluster Headache
Cluster Headache 		0.100 Biomarker disease BEFREE The purpose of this study was to evaluate the association between CH and the HCRTR2, ADH4 and CLOCK genes in a Chinese CH case-control sample. 29318394 2018
CUI: C0009088
Disease: Cluster Headache
Cluster Headache 		0.100 GeneticVariation disease BEFREE A total of 575 cluster headache patients from our LUCA study and 874 controls were genotyped for HCRTR2 SNP rs2653349 but no significant association with cluster headache was found (odds ratio 0.91 (95% confidence intervals 0.75-1.10), p = 0.319). 25398231 2015
CUI: C0009088
Disease: Cluster Headache
Cluster Headache 		0.100 GeneticVariation disease BEFREE The HCRTR2 1246G > A and the ADH4 925A > G polymorphisms have been associated with CH. 20425202 2010
CUI: C0009088
Disease: Cluster Headache
Cluster Headache 		0.100 GeneticVariation disease BEFREE Three new polymorphisms of the HCRTR2 gene resulted significantly associated with CH. 18399985 2008
CUI: C0009088
Disease: Cluster Headache
Cluster Headache 		0.100 GeneticVariation disease BEFREE Our study does not support a major contribution of the HCRTR2 G1246A polymorphism to the pathogenesis of migraine in contrast to its effects in cluster headache. 17883525 2007
CUI: C0009088
Disease: Cluster Headache
Cluster Headache 		0.100 GeneticVariation disease LHGDN Our data confirm that the G1246A polymorphism of the HCRTR2 gene may modulate the genetic risk for CH. 17563843 2007
CUI: C0009088
Disease: Cluster Headache
Cluster Headache 		0.100 GeneticVariation disease BEFREE Our results do not support a role of the HCRTR2 G1246A polymorphism in drug responses in CH. 17376114 2007
CUI: C0009088
Disease: Cluster Headache
Cluster Headache 		0.100 GeneticVariation disease BEFREE Our data confirm that the G1246A polymorphism of the HCRTR2 gene may modulate the genetic risk for CH. 17563843 2007
CUI: C0009088
Disease: Cluster Headache
Cluster Headache 		0.100 GeneticVariation disease BEFREE Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene. 16554494 2006
CUI: C0009088
Disease: Cluster Headache
Cluster Headache 		0.100 GeneticVariation disease BEFREE A genome-wide scan and HCRTR2 candidate gene analysis in a European cluster headache cohort. 16801656 2006
CUI: C0009088
Disease: Cluster Headache
Cluster Headache 		0.100 GeneticVariation disease BEFREE The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache. 15477554 2004
CUI: C0009088
Disease: Cluster Headache
Cluster Headache 		0.100 GeneticVariation disease LHGDN The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache. 15477554 2004