HCRTR2, hypocretin receptor 2, 3062

N. diseases: 37; N. variants: 11
Disease: Heart failure ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018801
Disease: Heart failure
Heart failure 		0.030 Biomarker disease BEFREE Indeed, OR-B, but not OR-A, by acting through orexin receptor-2 (OX2R), exerts direct cardioprotective effects in heart failure models. 30948623 2019
CUI: C0018801
Disease: Heart failure
Heart failure 		0.030 AlteredExpression disease BEFREE In human subjects with heart failure, there is a significant negative correlation between the expression of OX2R and the severity of the disease clinical symptoms, as assessed by the New York Heart Association (NYHA) functional classification. 30467191 2018
CUI: C0018801
Disease: Heart failure
Heart failure 		0.030 Biomarker disease BEFREE Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure. 26653627 2015