Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Among hypocretin replacement strategies, developing non-peptide hypocretin receptor agonists is currently the most encouraging since systemic administration of a newly synthesized, selective hypocretin receptor 2 agonist (YNT-185) has been shown to ameliorate symptoms of narcolepsy in murine models.
|
29623725 |
2018 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
HCRTR2-Abs are not common in narcolepsy unrelated to vaccination.
|
28364500 |
2017 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases.
|
29220370 |
2017 |
Narcolepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Hcrtr2 mutations underlie the etiology of canine narcolepsy, deficiencies in orexin-producing neurons are observed in the human disorder, and ablation of mouse orexin neurons or the Hcrt gene results in a narcolepsy-cataplexy phenotype.
|
22759794 |
2012 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
MGD |
To identify the neuronal circuits underlying narcolepsy, we produced a mouse model in which a loxP-flanked gene cassette disrupts production of the orexin receptor type 2 (OX2R; also known as HCRTR2), but normal OX2R expression can be restored by Cre recombinase.
|
21368172 |
2011 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
MGD |
Hcrtr1 and 2 signaling differentially regulates depression-like behaviors.
|
21377495 |
2011 |
Narcolepsy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To determine whether hypocretin receptor gene (hcrtR1 and hcrtR2) expression is affected after long-term hypocretin ligand loss in humans and animal models of narcolepsy.
|
18714784 |
2008 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
CTD_human |
By using microarray technology we have screened the expression of 29760 genes in the brains of Doberman dogs with a heritable form of narcolepsy (homozygous for the canarc-1 [HCRTR-2-2] mutation), and their unaffected heterozygous siblings.
|
17521418 |
2007 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Expression of the hypocretin/orexin receptor HCRTR2, which has been implicated in narcolepsy, correlated with sleep disturbance.
|
16376318 |
2006 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
We detected autoantibodies against hypocretin in 3 patients, hcrtrl in 1 patient, and hcrtr2 in 5 patients with narcolepsy.
|
16774153 |
2006 |
Narcolepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The orexin-2/hypocretin-2 (OX2R) receptor gene is mutated in canine narcolepsy and disruption of the prepro-orexin/hypocretin ligand gene results in both an animal model of narcolepsy and sporadic cases of the human disease.
|
15274044 |
2004 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
MGD |
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes.
|
12797957 |
2003 |
Narcolepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The positional cloning of the hypocretin receptor 2, the gene for autosomal recessive canine narcolepsy, has led to the development of a physical map spanning a large portion of canine chromosome 12 (CFA12), in a region corresponding to human chromosome 6p12-q13.
|
11350122 |
2001 |
Narcolepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, 11 sporadic cases of canine narcolepsy and two additional multiplex families were investigated for possible Hcrt and Hcrtr2 mutations.
|
11282968 |
2001 |
Narcolepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study of American and Icelandic patients with narcolepsy, the authors found no significant association between narcolepsy and single-nucleotide polymorphisms in the genes for hypocretin or its two known receptors, hypocretin receptor-1 and hypocretin receptor-2.
|
11723285 |
2001 |
Narcolepsy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models.
|
10615891 |
2000 |
Narcolepsy
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have determined that canine narcolepsy is caused by disruption of the hypocretin (orexin) receptor 2 gene (Hcrtr2).
|
10458611 |
1999 |