HDAC1, histone deacetylase 1, 3065

N. diseases: 277; N. variants: 1
Disease: Childhood Leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.030 Biomarker disease BEFREE HDAC1,2 inhibitor either alone or when combined with doxorubicin decreases leukemia burden in vivo in refractory Ph+ B-cell precursor ALL patient-derived xenograft mouse models. 28579617 2018
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.030 PosttranslationalModification disease BEFREE In summary, the presented data suggest a mechanism through which Ikaros and HDAC1 regulate the epigenetic signature in leukemia: via regulation of JARID1B transcription. 26655717 2016
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.030 Biomarker disease BEFREE However, the patterns of HDAC1 localization and the role of HDACs in leukemia pathogenesis remain to be elucidated. 21176959 2011