HDAC2, histone deacetylase 2, 3066

N. diseases: 257; N. variants: 3
Disease: Malignant tumor of colon ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.060 AlteredExpression disease BEFREE Since HDAC2-dependent NF-κB activity protects colon cancer cells from genotoxic stress, our data also suggest that high HDAC2 levels, which are frequently found in tumors, are linked to chemoresistance. 25704882 2015
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.060 AlteredExpression disease BEFREE Recent studies report that HDAC2 overexpression is associated with colon tumor progression and is a potential target for colon cancer prevention. 24218540 2014
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.060 AlteredExpression disease BEFREE Analysis of mRNA expression in colon cancer patients, showed a similar pattern of increase in claudin-1 and HDAC-2 mRNA expression throughout all stages of colon cancer. 19881542 2010
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.060 AlteredExpression disease BEFREE Finally, silencing of HDAC2 expression was sufficient to sensitize colon cancer cells to TNFalpha-induced apoptosis. 18314102 2008
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.060 GeneticVariation disease BEFREE Colon cancer cell lines and primary cancers were examined for mutations in HDAC2 by direct sequencing and capillary electrophoresis. 18834886 2008
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.060 AlteredExpression disease BEFREE Increased HDAC2 expression is found in the majority of human colon cancer explants, as well as in intestinal mucosa and polyps of APC-deficient mice. 15144953 2004