HDAC2, histone deacetylase 2, 3066

N. diseases: 257; N. variants: 3
Disease: Depressive disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.020 AlteredExpression disease BEFREE The goal of this study was to examine depression-like behavior during alcohol withdrawal and associated changes in histone acetylation and expression of histone deacetylase 2 (HDAC2) in the hippocampus, a brain region critical for mood regulation and depression. 30851364 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.020 Biomarker disease BEFREE Postmortem brain studies support dysregulated expression of the histone deacetylase enzymes, HDAC1 and HDAC2, as a central feature in diseases including schizophrenia, bipolar disorder, and depression. 27959513 2017