HDAC2, histone deacetylase 2, 3066

N. diseases: 257; N. variants: 3
Disease: leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia 		0.020 AlteredExpression disease BEFREE In addition, our study has shown that Belinostat and DZNep together with RA caused a depletion in HDAC1 and HDAC2 protein levels, HDAC2 gene expression and increased hyperacetylation of histone H4 in both leukemia cell lines. 28192098 2017
CUI: C0023418
Disease: leukemia
leukemia 		0.020 Biomarker disease BEFREE Altogether, this study provides strong evidence that high-expression CFTR plays an important role in the development of Ph+ leukemia through the HDAC2-mediated PTEN pathway. 28235656 2017