HDAC2, histone deacetylase 2, 3066

N. diseases: 257; N. variants: 3
Disease: Malignant neoplasm of liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.040 Biomarker disease BEFREE Our findings offer preclinical proof-of-concept for HDAC2 blockade as a systemic therapy for liver cancer. 24958469 2014
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.040 AlteredExpression disease BEFREE Oncogenic potential of CK2α and its regulatory role in EGF-induced HDAC2 expression in human liver cancer. 24616922 2014
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.040 Biomarker disease BEFREE MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer. 23499894 2013
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.040 AlteredExpression disease BEFREE In conclusion, we suggest that the aberrant regulation of HDAC2 may play a pivotal role in the development of HCC through its regulation of cell cycle components at the transcription level providing HDAC2 as a relevant target in liver cancer therapy. 22132221 2011