HDAC2, histone deacetylase 2, 3066

N. diseases: 257; N. variants: 3
Disease: Malignant neoplasm of pancreas ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.050 Biomarker disease BEFREE A combined approach targeting HDAC1/HDAC2 and MYC may present a novel and molecularly defined strategy to target mutant p53 in pancreatic cancer. 27721407 2017
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.050 AlteredExpression disease BEFREE Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer. 22147512 2012
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.050 Biomarker disease BEFREE HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells. 20398369 2010
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.050 Biomarker disease BEFREE E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex. 19362090 2009
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.050 Biomarker disease BEFREE HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA. 19528037 2009