HDAC2, histone deacetylase 2, 3066

N. diseases: 257; N. variants: 3
Disease: Primary malignant neoplasm of lung ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.050 Biomarker disease BEFREE However, <i>HDAC2</i> knockdown had a marginal effect on <i>p53</i>-null human lung cancer H1299 cells following ADR exposure. 30868056 2019
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.050 Biomarker disease BEFREE The identified DEGs such as retinoid X receptor alpha (<i>RXRA</i>)<i>,</i> cyclin-dependent kinase 2 (<i>CDK2</i>)<i>,</i> histone deacetylase 2 (<i>HDAC2</i>), and <i>KIT</i> might be the target genes of lung cancer by participating in different pathways such as ECM-receptor interaction. 31305128 2019
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.050 Biomarker disease BEFREE Endogenous HDAC2 directly correlates with BAP1 across a panel of lung cancer cell lines, and is downregulated in mesothelioma cell lines with genetic BAP1 inactivation. 25970771 2015
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.050 Biomarker disease BEFREE They further suggest that HDAC2 may exert a dominant effect on lung cancer cell survival by sustaining Mdm2-survivin levels. 25605253 2015
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.050 PosttranslationalModification disease BEFREE Taken together, we suggest that the aberrant regulation of HDAC2 and its epigenetic regulation of gene transcription in apoptosis and cell cycle components play an important role in the development of lung cancer. 22492270 2012