CFH, complement factor H, 3075

N. diseases: 393; N. variants: 150
Disease: Chronic central serous chorioretinopathy ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0730314
Disease: Chronic central serous chorioretinopathy
Chronic central serous chorioretinopathy 		0.040 GeneticVariation disease BEFREE Acute CSC, nonsevere cCSC, and severe cCSC all showed a similar association with the CFH and C4B genes, and the three phenotypes could not be distinguished based on the genetics. 31815877 2019
CUI: C0730314
Disease: Chronic central serous chorioretinopathy
Chronic central serous chorioretinopathy 		0.040 GeneticVariation disease BEFREE One locus on chromosome 1 at the complement factor H (CFH) gene reached genome-wide significance and was associated with an increased risk of cCSC (rs1329428; odds ratio [OR], 1.57 [95% CI, 1.38-1.80]; P = 3.12 × 10-11). 30073298 2018
CUI: C0730314
Disease: Chronic central serous chorioretinopathy
Chronic central serous chorioretinopathy 		0.040 GeneticVariation disease BEFREE Chronic central serous chorioretinopathy (cCSC) has recently been associated to variants in the complement factor H gene. 26305533 2015
CUI: C0730314
Disease: Chronic central serous chorioretinopathy
Chronic central serous chorioretinopathy 		0.040 GeneticVariation disease BEFREE Intriguingly, alleles in ARMS2 and CFH that confer risk of AMD may be protective for cCSC, and alleles in CFH that are protective for AMD confer risk for cCSC. 25439433 2015