Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
When the tumor reactivity of dominant clonotypic TCRs in each mouse was analyzed, 9 of 13 TCRs induced the secretion of IFNγ in response to, and showed killing of, B16F10 cells <i>in vitro</i>, and 2 of them showed strong antitumor activity <i>in vivo</i> Concerning their antigen specificity, 7 of them reacted to p15E peptide of endogenous murine leukemia virus-derived envelope glycoprotein 70, and the rest reacted to tumor-associated antigens expressed on EL4 lymphoma as well as B16 melanoma cells.
|
29475880 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Colony-formation experiments and in-vivo tumor xenografts suggested that syncytin-1 overexpression had oncogenic potential.
|
24013223 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The env gene transcripts evidenced significant differences in the human tumor/normal adjacent tissues (colon, liver, uterus, lung and testis).
|
19669627 |
2009 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interactions between Syncytin-1 and TGF-beta may contribute to the etiology of EnCa progression and also help to clarify the regulation of cell-cell fusions occurring in development and in other syncytial cell tumors.
|
17066266 |
2007 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We previously reported a 660-bp mouse mammary tumor virus (MMTV)-like env gene sequence in approximately 38% of human breast cancer DNA, but not in normal breasts or other tumors.
|
15205319 |
2004 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Elevated expression of the tumor suppressing protein p53 is associated with the presence of mouse mammary tumor-like env gene sequences (MMTV-like) in human breast cancer.
|
15377846 |
2004 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Jaagsiekte sheep retrovirus (JSRV) and ovine nasal adenocarcinoma virus (ONAV) replicate in the airway and cause epithelial cell tumors through the activity of their envelope (Env) proteins.
|
12596899 |
2003 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results suggested the hypothesis that the JSRV and ENTV Env proteins cause cancer by inhibiting the tumor suppressor activity of Hyal2.
|
12584308 |
2003 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Prompted by the observation of retroviral particle formation in teratocarcinoma cell lines and the consistent finding of antibodies against Gag and Env proteins encoded by human endogenous retrovirus (HERV)-K genomes in the sera of patients with classical seminoma, we studied ovarian and testicular germ cell tumours, their precursor lesions, dysgenetic gonads, and trophoblast lesions for expression of HERV-K sequences by in situ hybridization using radioactive and non-radioactive probes.
|
9524581 |
1998 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Molecular cloning and sequence analysis of the cDNAs derived from the myb transcripts show that ABPL-1 tumor produces a tripartate mRNA containing sequences derived from the viral gag and env genes fused to the myb coding region.
|
8808693 |
1996 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data indicate that 38-40% of human breast cancers contain gene sequences homologous to the MMTV env gene that are absent from other tumors and tissues.
|
7585568 |
1995 |