|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, ERK/MAPK signaling pathway is involved in the effects of HGF of promoting proliferation and regulating cell cycle and apoptosis of human colon cancer cells, providing a new approach for the treatment of colon cancer.
|
30675292 |
2019 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously shown that in dexamethasone (Dex)-treated CAFs derived from colon cancer, production and secretion of several factors related to cancer progression, such as tenascin C (TNC) and hepatocyte growth factor (HGF), were strongly suppressed.
|
29196164 |
2018 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-1α was expressed in human umbilical vein endothelial cells (HUVECs) and HT-29 and WiDr (colon cancer cell lines with higher liver metastatic potential).HGF was expressed only in fibroblast.
|
29062241 |
2017 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To determine whether hrIL-7/HGFβ has antitumor activity, we injected this hybrid cytokine into melanoma and colon cancer animal models, and then assessed the local tumor growth and tumor metastasis.
|
28861327 |
2017 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Additionally, dexamethasone can inhibit the expression of Tenascin C, hepatocyte growth factor, and TGFβ, which are all factors known for their impact on colon cancer cell invasion, in a glucocorticoid receptor-dependent manner.
|
25666906 |
2015 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MET, the tyrosine kinase receptor for hepatocyte growth factor, is frequently overexpressed in colon cancers with high metastatic tendency.
|
22179665 |
2012 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The mRNA and protein expression levels of HGF and c-Met were significantly higher in colon cancer than in matched normal mucosa.
|
22495710 |
2012 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, AAV-HGFK1+Ad-p53 cocktail therapy has a significantly higher therapeutic effect than AAV-HGFK1 or Ad-p53 alone and is a novel promising gene therapy for colon cancer.
|
18790766 |
2008 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the suppressive effects of adenoviral vector-mediated expression of NK4, an antagonist of hepatocyte growth factor (HGF), on human colon cancer in an athymic mouse model to explore the possibility of applying NK4 to cancer gene therapy.
|
17461494 |
2007 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study investigates the transcriptional changes induced by Ki-ras oncogene and HGF/Met signaling activation in colon cancer cell lines in vitro and in vivo.
|
16158056 |
2006 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
HGF upregulates and modifies subcellular distribution of proteins in colon cancer cell enterocytic differentiation.
|
11557528 |
2001 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mitogenic effects of HGF were determined in four human colon cancer cell lines by (3)H-thymidine incorporation studies.
|
10878450 |
2000 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Nonsteroidal anti-inflammatory drugs may prevent colon cancer through suppression of hepatocyte growth factor expression.
|
10082276 |
1999 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is concluded that HGF has an effect on both colon cancer cell motility and growth, which may be important in the control of the spread of colon cancer.
|
8386069 |
1993 |