|
Liver regeneration disorder
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Stab2-iCre<sup>tg/wt</sup>;Hgf<sup>fl/fl</sup> (Hgf<sup>ΔLSEC</sup>) mice were generated to abrogate Hgf expression selectively in LSEC from early fetal development onwards, to study global development, metabolic and endothelial zonation, and organ functions as well as liver regeneration in response to 70% partial hepatectomy (PH).
|
31783007 |
2020 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Whereas hepatocyte growth factor (HGF) and epidermal growth factor (EGF) are direct mitogens to hepatocytes, inflammatory cytokines such as TNFα and IL-6 also play essential roles in the liver regeneration process.
|
31154249 |
2019 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Transforming growth factor-β (TGF-β) and hepatocyte growth factor (HGF) are among the key signals involved in liver regeneration and as component of HPCs niche regulates HPCs biology.
|
31108004 |
2019 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hepatocyte proliferation was also promoted in partial hepatectomized rats by hPH treatment. hPH increased liver regeneration rate, double nucleic cell ratio, mitotic cell ratio, proliferating cell nuclear antigen (PCNA), and K<sub>i</sub>-67 positive cells in vivo as well as interleukin (IL)-6, tumor necrosis factor alpha (TNF-α), and hepatocyte growth factor (HGF).
|
30930420 |
2019 |
|
Liver regeneration disorder
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our data suggest that the degree of liver regeneration indicated by high levels of HGF within the liver is a dismissible factor in the post-KPE disease course.
|
31185750 |
2019 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
TNF-α, IL-6, HGF, TSP-1 and TGF-β1 were essential factors for the formation of tight junction and the establishment of hepatocytes polarity in liver regeneration.
|
29166570 |
2018 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Therefore, HGF and SDF-1 may represent important chemoattractants for transplanted BMC in the injured liver, where these cells can give rise to populations of extrahepatic macrophages, neutrophils and endothelial progenitor cells that can interact synergistically with other liver cells towards the modulation of an anti-fibrotic cytokine profile promoting the onset of liver regeneration.
|
29176797 |
2017 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes, and has been shown to prevent cirrhosis during liver regeneration.
|
28386375 |
2017 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results provide insight into the molecular mechanism for HGF-stimulated hepatocyte proliferation and liver regeneration: Arf6 recruits PIP5K1A to c-Met and activates it upon HGF stimulation to produce PIP<sub>2</sub> and subsequently PIP<sub>3</sub>, which in turn activates Akt to promote hepatocyte proliferation, thereby accelerating liver regeneration after liver injury.
|
28842595 |
2017 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In the in vitro experiments, LPS preconditioning of ASCs enhanced the mRNA expression levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), hepatocyte growth factor, and vascular endothelial growth factor, which evoke inflammatory response or liver regeneration.
|
25890074 |
2015 |
|
Liver regeneration disorder
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our results indicate that the proteolytic activity of ADAM10/17 is essential for regulating HGF/c-Met signalling during acute liver damage and following regeneration and that the differential serum levels of sMet together with expression of c-Met/HGF might be a useful indicator not only for damage, but also for ongoing liver regeneration.
|
23746173 |
2013 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hepatocyte growth factor/scatter factor (HGF/SF) stimulates hepatocyte DNA synthesis and protects against apoptosis; in vivo it promotes liver regeneration and reduces fibrosis.
|
22178588 |
2012 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Preparation of polyelectrolyte nanocomplexes containing recombinant human hepatocyte growth factor as potential oral carriers for liver regeneration.
|
22042676 |
2012 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The high amount of hepatocyte growth factor (HGF) is produced to promote liver regeneration by hepatectomy.
|
20596656 |
2010 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hepatocyte growth factor (HGF) is one of the potent growth factors for liver regeneration and has a strong effect on epithelial and nonepithelial cells.
|
17260004 |
2007 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hepatocyte growth factor (HGF) stimulates liver regeneration, accelerates restoration of hepatic function, and improves fibrosis.
|
16627068 |
2006 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
It has been proven that hepatocyte growth factor, transforming growth factor, epidermal growth factor, tumor necrosis factor-alpha, interleukins -1 and -6 are the main growth and promoter factors secreted after hepatic injury, partial hepatectomy and after a sequence of different and complex reactions to activate transcription factors, mainly nuclear factor kappaB and signal transduction and activator of transcription-3, affects specific genes to promote liver regeneration.
|
16458925 |
2006 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hepatocyte growth factor and c-Met inhibition by hepatic cell hypoxia: a potential mechanism for liver regeneration failure in experimental cirrhosis.
|
11839582 |
2002 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hepatocyte growth factor/scatter factor (HGF/SF) is one of the most important humoral mediators of liver regeneration.
|
10925356 |
2000 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hepatocyte growth factor plays a key role in liver regeneration but the role of liver in its synthesis in acute liver failure is unclear.
|
11117560 |
2000 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hepatocyte growth factor (HGF) was originally characterized as a strong inducer of liver regeneration.
|
9367839 |
1997 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hepatocyte growth factor (HGF) and transforming growth factor alpha (TGF-alpha) stimulate liver regeneration, whereas transforming growth factor beta 1 (TGF-beta 1) inhibits it in rats.
|
8690400 |
1996 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In 70%-hepatectomized rats, HGF stimulated liver regeneration and increased the level of blood proteins such as hepaplastin in a dose-dependent manner.
|
8586627 |
1995 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Human hepatocyte growth factor (hHGF), which is now known to be the same protein as the scatter factor and the tumor cytotoxic factor, is a heterodimeric protein with one heavy chain and one light chain linked together by a disulfide bond, and is thought to be involved in liver regeneration.
|
7489981 |
1995 |
|
Liver regeneration disorder
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This article summarizes the current position of research on HGF, and presents both clinical and scientific evidence that strongly implicates this factor in liver regeneration and cancer invasion and metastasis.
|
8252338 |
1993 |