|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this first study to select markers systematically on the basis of linkage disequilibrium across the entire NRG1 gene, we used haplotype-tagging single-nucleotide polymorphisms to identify single markers and haplotypes associated with schizophrenia and bipolar disorder in an independently ascertained Scottish population.
|
16940976 |
2007 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
To investigate the possible role of NRG1 in bipolar disorder.
|
15939841 |
2005 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study supports the hypothesis that NRG1 may play a role in the development of bipolar disorder, especially in psychotic subtypes, albeit with different alleles to previous association reports in schizophrenia and bipolar disorder.
|
19339916 |
2009 |
|
Bipolar Disorder
|
0.500 |
AlteredExpression
|
disease |
LHGDN |
We wished to investigate further the involvement of NRG1 in schizophrenia and bipolar disorder.
|
18466881 |
2008 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
PSYGENET |
In this study we investigated 36 single nucleotide polymorphisms within 10 genes previously associated with major depression and bipolar disorder, as well as with the response to their treatment (ABCB1, ABCB4, TAP2, CLOCK, CPLX1, CPLX2, SYN2, NRG1, 5HTR1A and GPRIN2).
|
23273899 |
2013 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
The dystrobrevin binding protein 1 (DTNBP1) and neuregulin 1 (NRG1) genes have been related to schizophrenia (SZ) and bipolar disorder (BP) by several whole-genome linkage and associations studies.
|
18234478 |
2008 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
The Neuregulin 1 (NRG1) gene was initially implicated in schizophrenia (SZ) and has recently been associated with bipolar disorder (BPD) in two studies.
|
19367584 |
2010 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this paper, we review extant studies involving neurocognitive-genetic and neuroimaging-genetic perspectives and particularly related to catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin-1 (NRG1) genes in SZ and BD.
|
21688113 |
2011 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
PSYGENET |
The neuregulin-1 (NRG1) gene is one of the best-validated risk genes for schizophrenia, and psychotic and bipolar disorders.
|
24865593 |
2014 |
|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These genes include neuregulin-1 (NRG1) polymorphisms of which have been associated with risk to bipolar disorder.
|
20374152 |
2009 |
|
Bipolar Disorder
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Levels of neuregulin 1 and 3 proteins in Brodmann's area 46 from subjects with schizophrenia and bipolar disorder.
|
19765633 |
2009 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Several disposition genes for schizophrenia (DTNBP1, NRG1, G72) were identified, whereas evidence for specific disposition genes in bipolar disorder is more limited.
|
14677079 |
2003 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Neuregulin 1 (NRG1) is a bipolar disorder susceptibility gene and a biomarker of major depressive disorder, which regulates pyramidal neuron activity via ErbB4 in parvalbumin interneurons.
|
24633675 |
2014 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
The replication of neuregulin 1 association on chromosome 8p by several investigators is the most convincing to date, and the presence of a syndrome similar to dementia praecox of 8p linked families, and the lack of linkage of bipolar disorder to this region is a testament to the ideas of Kraepelin more than 100 years ago.
|
14623361 |
2003 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Based on the function of neuregulin 1 (NRG1) in neurodevelopment, susceptibility to bipolar disorder presumably involves this gene.
|
24767010 |
2014 |
|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We examined the impact of neuregulin1 (NRG1), a probable susceptibility gene for schizophrenia and bipolar disorder, on brain function in a sample of 102 healthy 10-12 year old boys including 18 pairs of monozygotic twins, 24 pairs of dizygotic twins and 18 singletons.
|
19967439 |
2010 |
|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The neuregulin-1 (NRG1) gene is one of the best-validated risk genes for schizophrenia, and psychotic and bipolar disorders.
|
24865593 |
2014 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
LHGDN |
In this first study to select markers systematically on the basis of linkage disequilibrium across the entire NRG1 gene, we used haplotype-tagging single-nucleotide polymorphisms to identify single markers and haplotypes associated with schizophrenia and bipolar disorder in an independently ascertained Scottish population.
|
16940976 |
2007 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Neuregulin 1 (NRG1) is a frequently identified schizophrenia susceptibility gene that has also been associated with the psychotic features of bipolar disorder.
|
23022220 |
2013 |
|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Subjects with bipolar disorder (BD, n=358), schizophrenia (SZ, n=273), or unrelated controls (CO, n=479) were genotyped for three NRG1 variants.
|
21745728 |
2011 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of dopamine pathway genes NRG1 and LMX1A are associated with cognitive performance in bipolar disorder.
|
26534905 |
2015 |
|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Based on the function of neuregulin 1 (NRG1) in neurodevelopment, susceptibility to bipolar disorder presumably involves this gene.
|
24767010 |
2014 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
We wished to investigate further the involvement of NRG1 in schizophrenia and bipolar disorder.
|
18466881 |
2008 |
|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We examined the impact of neuregulin1 (NRG1), a probable susceptibility gene for schizophrenia and bipolar disorder, on brain function in a sample of 102 ten- to twelve-year-old children.
|
19449332 |
2009 |
|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism (SNP8NRG243177/rs6994992; C/T) in the promoter region of the brain-specific type IV neuregulin-1 gene ( NRG1) has been associated with psychiatric disorders (e.g. schizophrenia and bipolar disorder) that often present higher odds of smoking, alcohol and illicit drug use.
|
27353026 |
2017 |