|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism (SNP8NRG243177/rs6994992; C/T) in the promoter region of the brain-specific type IV neuregulin-1 gene ( NRG1) has been associated with psychiatric disorders (e.g. schizophrenia and bipolar disorder) that often present higher odds of smoking, alcohol and illicit drug use.
|
27353026 |
2017 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of dopamine pathway genes NRG1 and LMX1A are associated with cognitive performance in bipolar disorder.
|
26534905 |
2015 |
|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.
|
25944848 |
2015 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
PSYGENET |
The neuregulin-1 (NRG1) gene is one of the best-validated risk genes for schizophrenia, and psychotic and bipolar disorders.
|
24865593 |
2014 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Neuregulin 1 (NRG1) is a bipolar disorder susceptibility gene and a biomarker of major depressive disorder, which regulates pyramidal neuron activity via ErbB4 in parvalbumin interneurons.
|
24633675 |
2014 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Based on the function of neuregulin 1 (NRG1) in neurodevelopment, susceptibility to bipolar disorder presumably involves this gene.
|
24767010 |
2014 |
|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The neuregulin-1 (NRG1) gene is one of the best-validated risk genes for schizophrenia, and psychotic and bipolar disorders.
|
24865593 |
2014 |
|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Based on the function of neuregulin 1 (NRG1) in neurodevelopment, susceptibility to bipolar disorder presumably involves this gene.
|
24767010 |
2014 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
PSYGENET |
In this study we investigated 36 single nucleotide polymorphisms within 10 genes previously associated with major depression and bipolar disorder, as well as with the response to their treatment (ABCB1, ABCB4, TAP2, CLOCK, CPLX1, CPLX2, SYN2, NRG1, 5HTR1A and GPRIN2).
|
23273899 |
2013 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Neuregulin 1 (NRG1) is a frequently identified schizophrenia susceptibility gene that has also been associated with the psychotic features of bipolar disorder.
|
23022220 |
2013 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this paper, we review extant studies involving neurocognitive-genetic and neuroimaging-genetic perspectives and particularly related to catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin-1 (NRG1) genes in SZ and BD.
|
21688113 |
2011 |
|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Subjects with bipolar disorder (BD, n=358), schizophrenia (SZ, n=273), or unrelated controls (CO, n=479) were genotyped for three NRG1 variants.
|
21745728 |
2011 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
The Neuregulin 1 (NRG1) gene was initially implicated in schizophrenia (SZ) and has recently been associated with bipolar disorder (BPD) in two studies.
|
19367584 |
2010 |
|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We examined the impact of neuregulin1 (NRG1), a probable susceptibility gene for schizophrenia and bipolar disorder, on brain function in a sample of 102 healthy 10-12 year old boys including 18 pairs of monozygotic twins, 24 pairs of dizygotic twins and 18 singletons.
|
19967439 |
2010 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Association analysis of Neuregulin 1 candidate regions in schizophrenia and bipolar disorder.
|
20435087 |
2010 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study supports the hypothesis that NRG1 may play a role in the development of bipolar disorder, especially in psychotic subtypes, albeit with different alleles to previous association reports in schizophrenia and bipolar disorder.
|
19339916 |
2009 |
|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These genes include neuregulin-1 (NRG1) polymorphisms of which have been associated with risk to bipolar disorder.
|
20374152 |
2009 |
|
Bipolar Disorder
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Levels of neuregulin 1 and 3 proteins in Brodmann's area 46 from subjects with schizophrenia and bipolar disorder.
|
19765633 |
2009 |
|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We examined the impact of neuregulin1 (NRG1), a probable susceptibility gene for schizophrenia and bipolar disorder, on brain function in a sample of 102 ten- to twelve-year-old children.
|
19449332 |
2009 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
We investigated the association of NRG1 with BP in a large family sample, and then performed analyses according to the presence of psychotic features or mood-incongruent psychotic features.
|
19127563 |
2009 |
|
Bipolar Disorder
|
0.500 |
AlteredExpression
|
disease |
LHGDN |
We wished to investigate further the involvement of NRG1 in schizophrenia and bipolar disorder.
|
18466881 |
2008 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
The dystrobrevin binding protein 1 (DTNBP1) and neuregulin 1 (NRG1) genes have been related to schizophrenia (SZ) and bipolar disorder (BP) by several whole-genome linkage and associations studies.
|
18234478 |
2008 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
We wished to investigate further the involvement of NRG1 in schizophrenia and bipolar disorder.
|
18466881 |
2008 |
|
Bipolar Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this first study to select markers systematically on the basis of linkage disequilibrium across the entire NRG1 gene, we used haplotype-tagging single-nucleotide polymorphisms to identify single markers and haplotypes associated with schizophrenia and bipolar disorder in an independently ascertained Scottish population.
|
16940976 |
2007 |
|
Bipolar Disorder
|
0.500 |
Biomarker
|
disease |
LHGDN |
In this first study to select markers systematically on the basis of linkage disequilibrium across the entire NRG1 gene, we used haplotype-tagging single-nucleotide polymorphisms to identify single markers and haplotypes associated with schizophrenia and bipolar disorder in an independently ascertained Scottish population.
|
16940976 |
2007 |