|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that regulates transcriptional activation of several genes that are responsive to oxygen lack, including erythropoietin, vascular endothelial growth factor, various glycolytic enzymes and the GLUT-1 glucose transporter.
|
12062197 |
2002 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Hypoxia stimulates hypoxia-inducible factor-1alpha (HIF-1alpha), a transcriptional activator of VEGF.
|
12401798 |
2002 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Hypoxia-dependent up regulation of HIF-1alpha transcriptional activity is critical for survival of hypoxic chondrocyte, and it shapes up the fetal growth plate by inhibiting chondrocyte proliferation, increasing matrix accumulation and probably modulating cell size.
|
16144691 |
2006 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Hypoxia-inducible factors HIF-1 and HIF-2 are oxygen-sensitive basic helix-loop-helix transcription factors, which regulate biological processes that facilitate both oxygen delivery and cellular adaptation to oxygen deprivation.
|
16554418 |
2006 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
A role for hypoxia-inducible factor (HIF)-1 was suggested by the increase in HIF-1alpha as a result of hypoxia and by the increase in GLUT1 expression following treatment of BeWo with MG-132, a proteasomal inhibitor that increases HIF-1 levels.
|
17442736 |
2007 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Alltogether, our data indicate that HIF-1alpha and hypoxia play a crucial role for DC activation in inflammatory states, which is highly dependent on glycolysis even in the presence of oxygen.
|
18354193 |
2008 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
As a result, Zn chelation causes the accumulation of nonfunctional HIF-1alpha protein in both normoxia and hypoxia.
|
16579968 |
2006 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
As GLUT-1 was induced via Hif-1alpha under hypoxia in A204 RMS and A673 ES, these findings suggest that the Hif-1alpha-mediated increase in glucose uptake plays an important role in conferring apoptosis resistance.
|
17043658 |
2007 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha.
|
14699081 |
2004 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Cell density also correlated with increased staining for reductively activated pimonidazole (a marker for hypoxia), as well as with increased levels of the HIF-1alpha subunit and HIF transcriptional activity as determined by immunocytochemistry, Western blot, and luciferase reporter assays.
|
17289019 |
2007 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Cellular response to hypoxia involves signaling via Smad proteins.
|
12411310 |
2003 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Chromatin immunoprecipitation assay demonstrated that HIF-1 alpha directly bound to this region under normoxia, and this binding activity was significantly enhanced under hypoxia.
|
18339685 |
2008 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Chromatin immunoprecipitation identified a previously unappreciated binding site for the hypoxia inducible factor-1 (HIF-1), and promoter studies established its relevance by loss of repression following point mutation.
|
18779379 |
2009 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Dimethyloxallyl glycine, a stabilizer of hypoxia-inducible factor 1alpha (HIF1alpha), mimicked the hypoxia-mediated upregulation of visfatin, and YC1, an inhibitor of HIF1 cancelled the hypoxia-induced upregulation of visfatin mRNA.
|
16970912 |
2006 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
During hypoxia in A549 cells, HIF-1alpha promotes activity of the glycolysis pathway and decreases the pH of the culture medium, resulting in increased cellular apoptosis.
|
16438736 |
2006 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Endogenous hypoxia markers: case not proven!
|
18290322 |
2008 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Enhanced sensitivity of protein kinase B/Akt to insulin in hypoxia is independent of HIF1alpha and promotes cell viability.
|
17544543 |
2007 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Experiments were carried out on human ovarian carcinoma cells in four series: (1) control [Normoxia (5% CO2 in air), no treatment], (2) hypoxia (1% O2, 5% CO2, and 94% N2 for 48 h), (3) treatment with ASO targeted to HIF1A (48 h), and (4) combined action of hypoxia and ASO.
|
15832512 |
2005 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
First, HIF-1 controls the expression of gene products that stimulate angiogenesis, such as vascular endothelial growth factor, and promote metabolic adaptation to hypoxia, such as glucose transporters and glycolytic enzymes, thus providing a molecular basis for involvement of HIF-1 in tumor growth and angiogenesis.
|
11868612 |
2002 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Gel shift assays with a (32)P-labeled leptin promoter -116/HRE probe and nuclear extracts from hypoxia-treated cells indicated binding of the HIF1alpha/beta heterodimer, which was blocked with an excess of unlabeled -116/HRE probe or a HIF1-binding probe from the erythropoietin gene enhancer.
|
12084725 |
2002 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Here we examined the regulation of HIF-1alpha by hypoxia and nitric oxide (NO) in explants of human cerebrovascular smooth muscle cells.
|
14657004 |
2004 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Here, we provide the first evidence that sphingosine kinase 1 (SphK1), an oncogenic lipid kinase balancing the intracellular level of key signaling sphingolipids, modulates the transcription factor hypoxia inducible factor 1alpha (HIF-1alpha), master regulator of hypoxia.
|
18922940 |
2008 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Herein, we identify a mechanism of increased LT in SCD and show HIF-1alpha as a hypoxia-independent target of PlGF.
|
18945963 |
2009 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
However, longer exposure (16 h) in hypoxia resulted in a decreased HIF-1alpha protein level compared with early exposure (5 h).
|
12764143 |
2003 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Human placental hypoxia-inducible factor-1alpha expression correlates with clinical outcomes in chronic hypoxia in vivo.
|
17525282 |
2007 |