|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Primary meningioma cell cultures were established and cell culture experiments were performed using a hypoxia chamber to stimulate HIF-1alpha and VEGF production.
|
12296651 |
2002 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Endogenous hypoxia markers: case not proven!
|
18290322 |
2008 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Thioredoxin-interacting protein, a putative tumor suppressor gene, is induced in response to hypoxia in a HIF-1alpha-dependent manner in pancreatic cancer cells, resulting in increased apoptosis and increased sensitivity to platinum anticancer therapy.
|
18376310 |
2008 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Overexpression of HIF-1 alpha in normoxia induced the expression of a significant number of the hypoxia-dependent genes; however, it did not induce the pathophysiologic epithelial response.
|
12885785 |
2003 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
As GLUT-1 was induced via Hif-1alpha under hypoxia in A204 RMS and A673 ES, these findings suggest that the Hif-1alpha-mediated increase in glucose uptake plays an important role in conferring apoptosis resistance.
|
17043658 |
2007 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Hypoxia: dual effect on the expression of transferrin receptor in human melanoma A375 cell line.
|
17927572 |
2007 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha.
|
14671307 |
2003 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
We conclude that edaravone inhibits VEGF expression in astrocytes exposed to hypoxia, at least partly, through the down-regulation of HIF-1alpha.
|
17889387 |
2007 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Transcription of the gene coding for the tumor-associated antigen MN/carbonic anhydrase IX (CAIX) is regulated by hypoxia-inducible factor 1 (HIF-1).
|
12154057 |
2002 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
First, HIF-1 controls the expression of gene products that stimulate angiogenesis, such as vascular endothelial growth factor, and promote metabolic adaptation to hypoxia, such as glucose transporters and glycolytic enzymes, thus providing a molecular basis for involvement of HIF-1 in tumor growth and angiogenesis.
|
11868612 |
2002 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia.
|
18844219 |
2009 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Moreover, the levels of HIF-1alpha that we observed after exposure to moderate hypoxia were comparable between rho0 cells, which lack functional mitochondria, and the wild-type cells.
|
17666400 |
2007 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Here, we provide the first evidence that sphingosine kinase 1 (SphK1), an oncogenic lipid kinase balancing the intracellular level of key signaling sphingolipids, modulates the transcription factor hypoxia inducible factor 1alpha (HIF-1alpha), master regulator of hypoxia.
|
18922940 |
2008 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that regulates transcriptional activation of several genes that are responsive to oxygen lack, including erythropoietin, vascular endothelial growth factor, various glycolytic enzymes and the GLUT-1 glucose transporter.
|
12062197 |
2002 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
These results provide evidence of a key signalling pathway involving HIF-1alpha and TWIST that promotes metastasis in response to intratumoural hypoxia.
|
18297062 |
2008 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Our results provide persuasive evidence that the regulation of hTERT promoter activity by HIF-1 represents a mechanism for trophoblast growth during hypoxia and suggests that this may be a generalized response to hypoxia in various human disorders including resistance to cancer therapeutics by upregulating telomerase.
|
15199161 |
2004 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Thus, we proposed that the accumulated EGLN1 in hypoxia acts as a negative-feedback mechanism to modulate HIF-1alpha target gene expression.
|
16157596 |
2005 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
In conclusion, HIF-1alpha, which is related to tissue hypoxia in endometrial cancer, seems to be associated with overexpression of Ob and ObR.
|
17404022 |
2007 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
These results provide an insight into a possible link of hypoxia or HIF-1alpha and leukemic cell differentiation, and are possibly of significance to explore clinical potentials of hypoxia or hypoxia-mimicking agents and novel target-based drugs for differentiation therapy of leukemia.
|
14523474 |
2003 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Human placental hypoxia-inducible factor-1alpha expression correlates with clinical outcomes in chronic hypoxia in vivo.
|
17525282 |
2007 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
In line, gel shift analysis and chromatin immunoprecipitation confirmed binding of p50 and p65 NFkappaB subunits to the HIF-1alpha promoter under hypoxia.
|
17898080 |
2007 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Transfection experiments in HepG2 cells showed that both hypoxia and overproduction of HIF-1alpha specifically repressed the transcriptional activity of the rat afp regulatory region through the sequence 5'-CACGTGGG-3' located at -3625 to -3619.
|
11861398 |
2002 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
In addition to transcriptional activation mediated by HIF-1alpha, hypoxia has also been reported to inhibit translation.
|
17488873 |
2007 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Gel shift assays with a (32)P-labeled leptin promoter -116/HRE probe and nuclear extracts from hypoxia-treated cells indicated binding of the HIF1alpha/beta heterodimer, which was blocked with an excess of unlabeled -116/HRE probe or a HIF1-binding probe from the erythropoietin gene enhancer.
|
12084725 |
2002 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Prostate carcinoma cells selected by long-term exposure to reduced oxygen tension show remarkable biochemical plasticity via modulation of superoxide, HIF-1alpha levels, and energy metabolism.
|
17458899 |
2007 |